Ticlopidine
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- CAS-Nr.
- 55142-85-3
- Englisch Name:
- Ticlopidine
- Synonyma:
- pcr5332;PCR 5332;Ticlosin;Anagregal;Caudaline;TICIOPIDINE;TICLOPIDINE;PCR 5332|||Ticlid;5-(2-Chlorobenzyl);Ticlopidine USP/EP/BP
- CBNumber:
- CB7674370
- Summenformel:
- C14H14ClNS
- Molgewicht:
- 263.79
- MOL-Datei:
- 55142-85-3.mol
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Ticlopidine Eigenschaften
- Schmelzpunkt:
- 210-212 °C
- Siedepunkt:
- 117-120 °C(Press: 0.5 Torr)
- Dichte
- 1.273±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 7.10±0.20(Predicted)
- Farbe
- Off-White to Pale Yellow
- CAS Datenbank
- 55142-85-3(CAS DataBase Reference)
- NIST chemische Informationen
- Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-(55142-85-3)
- EPA chemische Informationen
- Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro- (55142-85-3)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Ticlopidine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Ticlopidine suppresses aggregation of thrombocytes and possesses antiaggregant activity. It is
believed that its action is connected to its effect on thrombocyte membranes and the reduction
in quantity of released adenosine diphosphate and serotonin, which facilitate aggregation of
thrombocytes. In wide-ranging clinical trials, ticlopidine presented a number of advantages
compared to aspirin.
Definition
ChEBI: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
Weltgesundheitsorganisation (WHO)
Ticlopidine, an inhibitor of platelet aggregation, was introduced in
1978 for use as an antithrombotic agent. By 1982 its use had been associated with
cases of agranulocytosis, severe leucopenia and impaired haemostasis. The drug
remains available in most countries in which it was approved with appropriate
warnings in the product information.
Allgemeine Beschreibung
Ticlopidine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c]pyridine hydrochloride(Ticlid), is useful in reducing cardiac events in patients withunstable angina and cerebrovascular events in secondaryprevention of stroke. It belongs to the thienopyridine classand facilitated the development of clopidogrel. One of thedrawbacks to this agent is its side effect profile, whichincludes neutropenia, and patients receiving this antithromboticshould have their blood levels monitored. Its mechanismof action is similar to that of clopidogrel, in that itinhibits the purinergic receptors on platelets.
Ticlopidine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ticlopidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 103)Lieferanten
55142-85-3()Verwandte Suche:
- 2-c)pyridine,4,5,6,7-tetrahydro-5-((2-chlorophenyl)methyl)-thieno(
- 5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine
- 5-(O-Chlorobenzyl)-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine
- PCR 5332
- pcr5332
- Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-((2-chlorophenyl)methyl)-
- Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-
- 5-(2-CHLORO-BENZYL)-4,5,6,7-TETRAHYDRO-THIENO[3,2-C]PYRIDINE
- TICLOPIDINE
- TICIOPIDINE
- Ticlopidine (base and/or unspecified salts)
- 2-[N-Methyl-N-(2-chlorobenzyl)aMinoethyl]thiophene
- Ticlopidine IMpurity (N-Methyl)
- 5-(2-Chlorobenzyl)
- Anagregal
- Caudaline
- Ticlosin
- Ticlopidine hydrochloride CRS
- Ticlopidine USP/EP/BP
- PCR 5332|||Ticlid
- 55142-85-3
- C14H14ClNS
- TF - TO
- Analytical Standards
- Alphabetic
- Analytical Chromatography Product Catalog
