Pyridin-2,3-dicarbonsure
|
|
|
- CAS-Nr.
- 89-00-9
- Bezeichnung:
- Pyridin-2,3-dicarbonsure
- Englisch Name:
- Quinolinic acid
- Synonyma:
- PYRIDINE-2,3-DICARBOXYLIC ACID;2,3-PYRIDINEDICARBOXYLIC ACID;QUIN;2,3-Pyridinedicarboxylic;Pyridine-2,3-dicarboxylate;2,3-PyridinedicarboxylicAcid99%;109/KG;NSC 18836;NSC 13127;NSC 403247
- CBNumber:
- CB7316162
- Summenformel:
- C7H5NO4
- Molgewicht:
- 167.12
- MOL-Datei:
- 89-00-9.mol
|
Pyridin-2,3-dicarbonsure Eigenschaften
- Schmelzpunkt:
- 188-190 °C (dec.) (lit.)
- Siedepunkt:
- 295.67°C (rough estimate)
- Dichte
- 1.5216 (rough estimate)
- Brechungsindex
- 1.6280 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- 10g/l
- Aggregatzustand
- Crystalline Powder
- pka
- 2.43(at 25℃)
- Farbe
- White to light yellow-beige
- Geruch (Odor)
- odorless
- Wasserl?slichkeit
- 0.55 g/100 mL
- Merck
- 14,8073
- BRN
- 137110
- InChIKey
- GJAWHXHKYYXBSV-UHFFFAOYSA-N
- CAS Datenbank
- 89-00-9(CAS DataBase Reference)
- EPA chemische Informationen
- 2,3-Pyridinedicarboxylic acid (89-00-9)
Pyridin-2,3-dicarbonsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R33:Gefahr kumulativer Wirkungen.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37:Geeignete Schutzhandschuhe tragen.
Chemische Eigenschaften
White powder;Light yellow powder
Verwenden
Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an ?excitotoxic? metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.
Biosynthese
The 3-hydroxyanthranilic acid oxygenase (3-HAO) catalyzes the conversion of 3-hydroxyanthranilic acid (3-HA) acid to an unstable intermediate, aminocarboxymuconic semialdehyde, which then preferentially converts to QUIN by a nonenzymatic cyclisation. This intermediate compound can also produce picolinic acid instead of QUIN. Finally, QUIN is catabolized to NAD+ and carbon dioxide by the action of quinolinate phosphoribosyl transferase (QPRT). This enzyme has been identified in rat and human CNS tissue[1].
Hazard
A poison by skin contact. Moderately toxic
by ingestion. A mild skin irritant.
Industrielle Verwendung
The use of quinolinic acid during flotation of hematite results in the adsorption of quinoline on hematite, allowing amine to selectively adsorb onto the hematite surface.
Biologische Aktivit?t
Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.
Sicherheitsprofil
A poison by skin contact. Moderately toxic by ingestion. Experimental reproductive effects. A mdd skinn irritant. When heated to decomposition it emits toxic vapors of NOx.
Pyridin-2,3-dicarbonsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pyridin-2,3-dicarbonsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 587)Lieferanten
89-00-9(Pyridin-2,3-dicarbonsure)Verwandte Suche:
Diethyl-1,4-dihydro-2,6-dimethylpyridin-3,5-dicarboxylat
Ethoxychin
Pyridin
Isochinolin
Dipiperidinomethan
Carbonsuren, Di-, C4-6-
ACETIC ACID
Picolinic acid chromium(III) salt
2,6-Dimethylpyridin
5,6,7,8-Tetrahydroisochinolin
Zitronensure
Folsure
Glycin
ASCORBICACID
Quinclorac
Pyridin-2,5-dicarbonsure
Pyridin-3,5-dicarbonsure
Pyridin-2,6-dicarbonsure
- QuinolinicAcid>99%
- Pyridin-2,3-dicarbonsaeure
- 2,3-PYRIDINEDICARBOXYLIC ACID (QUINOLINIC ACID)
- 2,3-pyridine dicarbo
- AKOS BBS-00003814
- AKOS AUF2085
- Quinolinic Acid 99%
- 2,3-Pyridinedicarboxylic acid, 99% 100GR
- 2,3-Pyridinedicarboxylic acid, 99% 25GR
- NSC 13127
- NSC 18836
- NSC 403247
- 2,3-PYRIDINEDICARBOXYLIC ACID FOR SYNTHE
- Pyridinecarboxylic acid-2,3- two
- 2,3-Pyridinedicarboxylic acid 99%
- 2,3-PYRIDINEDICARBOXYLIC ACID
AKOS AUF2085
- 2,3-pyridinediacrboxylic acid
- Pyridine-2,3-dicarboxylic acid (quinolinic acid)
- 109/KG
- 2,3-Pyridinedicarboxylic acid Vetec(TM) reagent grade, 98%
- RARECHEM AL BO 0810
- QUINOLIC ACID
- QUINOLINIC ACID
- 2,3 PYRIDINE DICARBOXYLIC ACID (AS PER INVOICE AND PACKING LIST)
- PYRIDINE-2,3-DICARBOXYLI ACID
- 2,3-PyridinedicarboxylicAcid>
- Pyridine-2,3-Dicarboxylic Acid,99%,
- 2,3-PyridinedicarboxyL
- 2,3-PyridinedicarboxylicAcid99%
- 2,3-Pyridinedicarboxylic
- 2,3-PYRIDINEDICARBOXYLIC ACID
- PYRIDINE-2,3-DICARBOXYLIC ACID
- Pyridine-2,3-dicarboxylate
- QUIN
- Quinolinic acid (2,3-pyridinedihydroxy acid)
- Pyridine Dicarbonylic Acid
- 13C4,15N]-2,3-Pyridinedicarboxylic Acid
- 89-00-9
- 98-00-9
- Building Blocks
- C7 and C8
- CARBOXYLIC ACID
- Pyridines
- Quinolines
- Heterocyclic Building Blocks
- Pyridine series
- Pyridine
- pyridine derivative
- Carboxylic Acids
- Pyridines
- Heterocyclic Compounds
- Heterocycles
- Inhibitors
- Carboxylic Acids
- Medical Intermediates
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
