S-Trityl-L-cysteine
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- CAS-Nr.
- 2799-07-7
- Englisch Name:
- S-Trityl-L-cysteine
- Synonyma:
- H-CYS(TRT)-OH;Dimethyl 5-bromopyridine-2,3-dicarboxylate;H-L-Cys(Trt)-OH;S-Tritylcysteine;H-Cys(Trt)-OH (Cys of Animal Origin);NSC 83265;L-Cys(Trt)-OH;CYSTEINE(TRT)-OH;EG5 INHIBITOR II;TRITYL-L-CYSTEINE
- CBNumber:
- CB7164332
- Summenformel:
- C22H21NO2S
- Molgewicht:
- 363.47
- MOL-Datei:
- 2799-07-7.mol
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S-Trityl-L-cysteine Eigenschaften
- Schmelzpunkt:
- 182-183 °C (dec.)(lit.)
- Siedepunkt:
- 524.7±50.0 °C(Predicted)
- Dichte
- 1.1342 (rough estimate)
- Brechungsindex
- 111 ° (C=0.8, 0.04mol Ethanolic HCl)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Soluble in DMSO (up to 20 mg/ml).
- Aggregatzustand
- White to off-white solid.
- pka
- 2.22±0.10(Predicted)
- Farbe
- White or off-white
- Optische Aktivit?t
- [α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl
- BRN
- 2339626
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
- CAS Datenbank
- 2799-07-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
22-24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
AY7710000 |
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| HS Code |
29309090 |
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| Toxizit?t |
dog,LDLo,intravenous,150mg/kg (150mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. PB81-109993, |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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S-Trityl-L-cysteine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
almost white to light yellow granular powder
Verwenden
A protected cysteine for peptide synthesis. S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression. It has proven antitumor activity as shown in the NCI 60 tumor cell line screen.
Biologische Aktivit?t
Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC 50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC 50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC 50 of 700 nM. Displays antitumor activity.
S-Trityl-L-cysteine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
S-Trityl-L-cysteine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 259)Lieferanten
2799-07-7()Verwandte Suche:
- S-TRITYL-L-CYSTEINE
- TRITYL-L-CYSTEINE
- S-TRITYL-L-CYSTEINE CRYSTALLINE
- (+)-S-TRITYL-L-CYSTEINE 97%
- L-Cysteine, -3,3-D2-S-Trityl
- (R)-2-Amino-3-(tritylthio)propionic acid
- (R)-S-Tritylcysteine
- S-Trityl-(R)-cycteine
- S-TRITYL-L-CYSTEINE extrapure
- (2R)-2-AMino-3-[(triphenylMethyl)thio]propanoic Acid
- S-Trityl-(R)-cysteine
- Tritylthioalanine
- S-Trityl-L-cysteine,97%
- (R)-2-AMino-3-tritylsulfanyl-propionic acid
- L-CYSTEINE, S-TRITYL
- 3-(tritylthio)-l-alanin
- 3-tritylthio-l-alanine
- s-(triphenylmethyl)-l-cystein
- L-Cys(Trt)-OH
- S-Trityl-L-cysteine≥ 98% (HPLC)
- CYSTEINE(TRT)-OH
- EG5 INHIBITOR II
- NSC 83265
- S-(TRIPHENYLMETHYL)-L-CYSTEINE
- (+)-S-TRITYL-L-CYSTEINE
- L-Cysteine, S-(triphenylmethyl)-
- S-Trityl-L-cysteine USP/EP/BP
- H-Cys(Trt)-OH (Cys of Non Animal Origin)
- (2R)-2-ammonio-3-[(triphenylmethyl)thio]propanoate
- (2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
- Dimethyl 5-bromopyridine-2,3-dicarboxylate
- H-L-Cys(Trt)-OH
- S-Tritylcysteine
- H-CYS(TRT)-OH
- H-Cys(Trt)-OH (Cys of Animal Origin)
- S-Tritylcysteine,Kinesin,StritylLCysteine,Apoptosis,328542,inhibit,cell cycle arrest,Inhibitor,NSC 83265,antitumor activities,NSC-83265,ATPase activity,kinesin Eg5,NSC83265,S trityl L Cysteine
- Tritylthioalanine (H-Cys(Trt)-OH)
- Impurity IIa-2 (S-triphenylmethylL-cysteine)
- 2799-07-7
- 2799-7-7
- 279-07-7
- 2799-07-07
- 7/7/2799
- 2799/7/7
- 328542
- C6H53CSCD2CHNH2COOH
- C6H53CSCH2CHNH2CO2H
- Specialty Synthesis
- Peptide Synthesis
- Cysteine/Cystine
- CARBOXYLIC ACID
- Amino Acid Derivatives
- Cell Cycle Regulation
- Amino Acid Derivatives
- Amino Acids & Derivatives
- Aromatics
- Chiral Reagents
- Enzyme substrates
