(S)-2-Phenylpyrrolidine
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- CAS-Nr.
- 59347-91-0
- Englisch Name:
- (S)-2-Phenylpyrrolidine
- Synonyma:
- (S)-2-Phenylpyrrolidine;(2S)-2-Phenylpyrrolidine;(2S)-2α-Phenylpyrrolidine;(S)-2-PHENYLPYRROLIDINE HCl;Pyrrolidine, 2-phenyl-, (2S)-
- CBNumber:
- CB6875464
- Summenformel:
- C10H13N
- Molgewicht:
- 147.22
- MOL-Datei:
- 59347-91-0.mol
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(S)-2-Phenylpyrrolidine Eigenschaften
- Siedepunkt:
- 237.0±19.0 °C(Predicted)
- Dichte
- 0.988±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 10.13±0.10(Predicted)
(S)-2-Phenylpyrrolidine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
(S)-2-Phenylpyrrolidine is an amine that has been synthesized for use in research. It is chiral and can exist as either the levorotatory or dextrorotatory form. It interacts with the tropomyosin receptor, which is a protein found on the surface of muscle cells. This interaction prevents calcium ions from binding to tropomyosin, thereby preventing muscle contraction.
Reaktionen
(S)-2-Phenylpyrrolidine could be react with N-{3-nitro-4-[(oxan-4-ylmethyl)amino]benzenesulfonyl}-4-{2-oxo-7-azaspiro[3.5]nonan-7- y l}-2-[( 11 R, 15S)-4-{[2-(trimethy Isi ly l)ethoxy]methy I}- 13, 16-dioxa-2,4, 10- triazatetracyclo[7.7.0.0A{3,7}.0A{11,15}]hexadeca-1(9),2,5,7-tetraen-10-yl]benzamide to synthsize a intermediate of BCL-2 inhibitor. It can also be use in the preparation of the Inhibitors of ubiquitin specific protease 19 (USP19) through amine group coupling.
Synthese
Into a 100 mL round-bottom flask were added tert-butyl (2S)- 2-phenylpyrrolidine-1-carboxylate (70 mg, 0.3 mmol, 1.0 eq) and CHsCh .0 mL), TFA (0.5 mL) at 25°C. The resulting mixture was stirred for 3 hours at 25°C. The resulting mixture was concentrated under reduced pressure. This resulted in (S)-2-Phenylpyrrolidine (40 mg, 96.0%) as colorless oil.
(S)-2-Phenylpyrrolidine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(S)-2-Phenylpyrrolidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 87)Lieferanten
59347-91-0()Verwandte Suche:
- (S)-2-Phenylpyrrolidine
- (2S)-2-Phenylpyrrolidine
- (2S)-2α-Phenylpyrrolidine
- (S)-2-PHENYLPYRROLIDINE HCl
- Pyrrolidine, 2-phenyl-, (2S)-
- 59347-91-0
- pharmaceutical intermediate
- Chiral heterocyclic compounds
