Ketorolac
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- CAS-Nr.
- 74103-06-3
- Englisch Name:
- Ketorolac
- Synonyma:
- Ketorolac acid;Acular;Fluoxetin;(S)-Ketorolac;5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid;Dolac;rs37619;Lixidol;Tm-asyn;Toratex
- CBNumber:
- CB6392833
- Summenformel:
- C15H13NO3
- Molgewicht:
- 255.27
- MOL-Datei:
- 74103-06-3.mol
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Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RIDADR |
3249 |
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| HazardClass |
6.1(a) |
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| PackingGroup |
II |
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| HS Code |
2933998090 |
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| Toxizit?t |
LD50 orally in mice: ~200 mg/kg (Rooks) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Ketorolac Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Light yellow solid
Verwenden
antiarrhythmic
Indications
Ketorolac (Toradol), an NSAID chemically related
to indomethacin and tolmetin, is mainly used as an analgesic,
not for the treatment of inflammatory disease. It
is available in oral, parenteral, and topical formulations.
Weltgesundheitsorganisation (WHO)
Ketorolac is a nonsteroidal anti-inflammatory agent used in the
management of moderate to severe acute post-operative pain. It remains on the
market in many countries with restrictions on its use.
Biologische Funktion
Ketorolac (Toradol) is an NSAID with very mild antiinflammatory
and antipyretic activity. It is a potent analgesic
for postoperative pain. Its efficacy is equivalent to
that of low doses of morphine in the control of pain. For
this reason it is often combined with opioids to reduce
opioid dose and related side effects while providing adequate
pain relief. It is also used to replace the opioids in
some patients with opioid sensitivity. The mechanism of
action of ketorolac involves the inhibition of COX and
decreased formation of prostaglandins. However, some
evidence exists that ketorolac may stimulate the release
of endogenous opioids as a part of its analgesic activity.
Allgemeine Beschreibung
Ketorolac tromethamine (Toradol), marketed as a mixture of(R)- and (S)-ketorolac enantiomers, is a potent NSAID analgesicindicated for the treatment of moderately severe, acutepain. It should be noted that the pharmacokinetic dispositionof ketorolac in humans is subject to marked enantioselectivity.Thus, it is important to monitor the individual blood levelsso an accurate assessment of its therapeutic action can bemade correctly. However, it should be noted that, beingone of the conventional NSAIDs with highest risk of GIcomplications, its administration should not exceed 5 days.
Ketorolac Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ketorolac Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 267)Lieferanten
74103-06-3()Verwandte Suche:
- Ketorolac Solution, 100ppm
- Ketorolac, >=98%
- 3-dihydro-5-benzoyl-(+-)-1h-pyrrolizine-1-carboxylicaci
- rs37619
- KETOROLAC
- KETOROLAC-D5
- KETOROLAC TROMETHAMINE, USP STANDARD
- 5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-ca
- Ketoralac
- 3-dihydro-5-benzoyl- (+-)-1h-pyrrolizine-1-carboxylic acid
- Dolac
- Lixidol
- Tm-asyn
- Toratex
- (1S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
- (1S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1β-carboxylic acid
- 5-phenylcarbonyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
- Ketorolac-13C6
- (1RS)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
- [1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]ammonium
- 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
- Ketorolac trometamol for peak identification CRS
- Ketorolac trometamol CRS
- 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic?acid. OR (Ketorolac Base)
- Ketorolac USP/EP/BP
- Ketorolac (RS37619)
- KetorolacQ: What is
Ketorolac Q: What is the CAS Number of
Ketorolac Q: What is the storage condition of
Ketorolac Q: What are the applications of
Ketorolac
- Ketorolac 13C6Q: What is
Ketorolac 13C6 Q: What is the CAS Number of
Ketorolac 13C6 Q: What is the storage condition of
Ketorolac 13C6 Q: What are the applications of
Ketorolac 13C6
- Fluoxetin
- Acular
- (S)-Ketorolac
- Ketorolac acid
- 5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid
- Ketonic acid
- Ketorolac Trometamol Monomer
- KETOROLAC ACID / 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1- carboxylic acid / KETOROLAC Intermediate
- Keterolac Tromethamine
- 74103-06-3
- C913C6H13NO3
- C15H8NO3D5
- Other APIs
- API's
