1-Methylpiperidine-4-carboxylic acid hydrochloride
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- CAS-Nr.
- 71985-80-3
- Englisch Name:
- 1-Methylpiperidine-4-carboxylic acid hydrochloride
- Synonyma:
- BIO-FARMA BF002150;RARECHEM AH CK 0139;TIMTEC-BB SBB003751;Lasmiditan Impurity 45;N-MethylisonipecoticacidHCl;4-CARBOXY-1-METHYL-PIPERIDINE HCL;1-Methyl-piperidine-4-carboxylic a;Methylpiperidincarbonsurehydrochlorid;1-Methyl-4-piperidinecarboxylic acid HCl;1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID HCL
- CBNumber:
- CB6341912
- Summenformel:
- C7H14ClNO2
- Molgewicht:
- 179.64
- MOL-Datei:
- 71985-80-3.mol
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1-Methylpiperidine-4-carboxylic acid hydrochloride Eigenschaften
- Schmelzpunkt:
- 226-228°C (dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- Aggregatzustand
- solid
- Farbe
- Off-white
- InChI
- InChI=1S/C7H13NO2.ClH/c1-8-4-2-6(3-5-8)7(9)10;/h6H,2-5H2,1H3,(H,9,10);1H
- InChIKey
- NLUDEWJJEMHIIL-UHFFFAOYSA-N
- SMILES
- N1(C)CCC(C(O)=O)CC1.[H]Cl
- CAS Datenbank
- 71985-80-3(CAS DataBase Reference)
1-Methylpiperidine-4-carboxylic acid hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Off-white solid
Synthese
The synthesis method of 1-Methylpiperidine-4-carboxylic acid Hydrochloride is shown below: Charge isonipecotic acid, palladium, and purified water into a reaction vessel. Heat the resulting mixture to 90 to 95° C. Charge formic acid and formaldehyde to the vessel. Cool the resulting mixture to 20 to 30° C. Filter the reaction mixture through GF/F. Wash the filter cake with purified water. Concentrate the combined filtrates to ca 2 vol at atmospheric pressure. Adjust the temperature 65 to 75° C. Charge conc—hydrochloric acid to the vessel. Charge acetonitrile to the vessel at ≧70° C. and concentrate the solution to ca 2 vol at atmospheric pressure. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 2 vol. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 3 vol. Check the water content by KF analysis of the supernatant liquors using AX reagent. Cool the reaction mixture to 20 to 25° C. Stir the reaction mixture for 1 to 2 hours. Filter the reaction mixture. Wash the filter cake with acetonitrile. Dry the product up to 50° C. until ≦0.5% w/w by LOD and ≦0.2% w/w water.
1-Methylpiperidine-4-carboxylic acid hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-Methylpiperidine-4-carboxylic acid hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 163)Lieferanten
- 4-CARBOXY-1-METHYL-PIPERIDINE HCL
- BIO-FARMA BF002150
- 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID HCL
- 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
- 1-METHYLPIPERIDINO-4-CARBOXYLIC ACID HYDROCHLORIDE
- 1-METHYL-4-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
- TIMTEC-BB SBB003751
- RARECHEM AH CK 0139
- 4-Carboxy-1-methylpiperidine hydrochloride, 1-Methylisonipecotic acid hydrochloride
- -4-1-Methyl piperidineforMic acidhydrochloride
- 4-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1)
- Methylpiperidincarbonsurehydrochlorid
- 1-Methyl-piperidine-4-carboxylic acid hydochloride, 98%
- N-MethylisonipecoticacidHCl
- 1-Methylpiperidine-4-carboxylic acid hydrochloride 98%
- 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID X HCL
- 1-Methylpiperidine-4-carboxylic acid hydrochloride ,98%
- 1-Methyl-4-piperidinecarboxylic acid HCl
- 1-Methylpiperdine-4-carboxylic acid hydrochloride
- 1-Methyl-4-piperidinecarboxylic acid，hydrochloride (1:1)(For export only)
- 1-Methyl-piperidine-4-carboxylic a
- 1-methyl-4-Piperidinecarboxylic acid hydrochloride (1:1)
- N-Methylpiperidine-4-carboxylic acid hydrochloride
- 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
- Lasmiditan Impurity 45
- 71985-80-3
- Piperidine
