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L-(+)-β-Mercaptovalin

L-Penicillamine Struktur
1113-41-3
CAS-Nr.
1113-41-3
Bezeichnung:
L-(+)-β-Mercaptovalin
Englisch Name:
L-Penicillamine
Synonyma:
l-valin;H-PEN-OH;3-MERCAPTO-L-VALINE;3,3-DIMETHYL-L-CYSTEINE;L-Pen-OH;L-(+)-B2;NSC 241261;3-Mercapto-;3-THIOL-VALINE;-Penicillamine
CBNumber:
CB6302922
Summenformel:
C5H11NO2S
Molgewicht:
149.21
MOL-Datei:
1113-41-3.mol

L-(+)-β-Mercaptovalin Eigenschaften

Schmelzpunkt:
206 °C (dec.)(lit.)
Siedepunkt:
251.8±35.0 °C(Predicted)
alpha 
61.9 º (C=0.5 IN 1 M NAOH)
Dichte
1.113 (estimate)
Brechungsindex
63 ° (C=1, 1mol/L NaOH)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
Aqueous Base (Sparingly), DMSO (Slightly, Heated), Water (Slightly)
pka
2.13±0.12(Predicted)
Aggregatzustand
Crystalline Powder
Farbe
White to almost white
Optische Aktivit?t
[α]24/D +61.9°, c = 0.5 in 1 M NaOH
Merck 
14,7088
BRN 
1722374
Stabilit?t:
Hygroscopic
InChIKey
VVNCNSJFMMFHPL-GSVOUGTGSA-N
CAS Datenbank
1113-41-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,Xn
R-S?tze: 36/37/38-40-20/21/22
S-S?tze: 26-36-22-24/25
WGK Germany  2
RTECS-Nr. YV9445500
HS Code  29309090
Toxizit?t LD50 i.p. in rats: 350 mg/kg (Jaffe)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

L-(+)-β-Mercaptovalin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.

Chemische Eigenschaften

white to almost white crystalline powder

Verwenden

As a Penicillin metabolite, L-Penicillamine can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.

Indications

Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness.The response to penicillamine is usually delayed (4–12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug’s efficacy is limited; thus, penicillamine is seldom used to treat rheumatoid arthritis.

Definition

ChEBI: The L-enantiomer of penicillamine.

Mechanism of action

The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson’s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication.

Pharmakologie

Penicillamine is readily absorbed from the GI tract and is rapidly excreted in the urine, largely as the intact molecule. Gradually increasing its dose minimizes side effects, which necessitate discontinuance of penicillamine therapy in perhaps one-third of patients. The most common side effects are maculopapular pruritic dermatitis, GI upset, loss of taste sensation, mild to occasionally severe thrombocytopenia and leukopenia,and mild proteinuria, which at times may progress to the nephritic syndrome. Discontinuance of therapy usually results in a rapid disappearance of side effects.

Sicherheitsprofil

A poison by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx and SOx.

l?uterung methode

Same as preceding entry for its enantiomer. [Beilstein 4 IV 3228.]

L-(+)-β-Mercaptovalin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


L-(+)-β-Mercaptovalin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 225)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.
+86-18616643091 +86-18616643091
info@rochipharma.com China 246 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Zhejiang ZETian Fine Chemicals Co. LTD
+8618957127338
stella@zetchem.com China 2136 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830
figo.gao@foxmail.com China 8497 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5906 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58

1113-41-3(L-(+)-β-Mercaptovalin)Verwandte Suche:


  • 3-THIOL-VALINE
  • TIMTEC-BB SBB000102
  • L-BETA,BETA-DIMETHYLCYSTEINE
  • L-BETA-MERCAPTOVALINE
  • L-(+)-PENICILLAMINE
  • L-PENICILLAMINE
  • L(+)-2-AMINO-3-MERCAPTO-3-METHYLBUTANOIC ACID
  • H-BETA,BETA-DIMETHYL-CYS-OH
  • H-CYS(3-ME 2)-OH
  • BETA,BETA-DIMETHYL-L-CYSTEINE
  • PENICILLAMINE(L-)
  • L-Penicillamine
  • L-Penicillamine≥ 99.0% (Titration: anhydrous basis)
  • 3-mercapto-l-valin
  • L-(+)-PENICILLAMINE, 98+%
  • L-PENICILLAMINE 99.5+%
  • 3,3-Dimethyl-L-cysteine~3-Mercapto-L-valine
  • (R)-Penicillamine
  • L-Valine, 3-mercapto- (9CI)
  • NSC 241261
  • Valine, 3-mercapto-, L- (8CI)
  • 3,3-Dimethyl-L-cysteine, 3-Mercapto-L-valine, L-(+)-2-Amino-3-mercapto-3-methylbutanoic acid
  • 3,3-Dimethyl-L-cysteine, 3-Mercapto-L-valine, L-(+)-2-Amino-3-mercapto-3-methylbutanoic acid β,β-Dimethyl-L-cysteine
  • [R,(+)]-2-Amino-3-mercapto-3-methylbutyric acid
  • L-(+)-β-mercaptovaline
  • 3-Mercapto-
  • L-PenicillaMine-d6
  • L-beta,beta-Dimethylcysteine L-beta-Mercaptovaline
  • H-b,b-DiMethyl-Cys-OH, H-b-Mercapto-Val-OH
  • L-Pen-OH
  • L-PenicillaMine 99%
  • Penicillamine Impurity 4(L-Penicillamine)
  • (2R)-2-amino-3-methyl-3-sulfanylbutanoic acid
  • L-Penicillamine>
  • L-Valine, 3-mercapto-
  • L-Penicillamine ISO 9001:2015 REACH
  • L-(+)-B2
  • -mercaptovaline
  • 3-MERCAPTO-L-VALINE
  • 3,3-DIMETHYL-L-CYSTEINE
  • H-PEN-OH
  • l-valin
  • 3-Sulfanyl-L-Valine
  • L-(+)-β-mercaptovaline
  • -Penicillamine
  • L-PENCILLAMINE
  • 1113-41-3
  • AMINE
  • Specialty Synthesis
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Amino Acids & Derivatives
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Amino Acids
  • Biochemistry
  • non-Proteinorganic Amino Acids
  • 1
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