天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Terbinafine

Terbinafine Struktur
91161-71-6
CAS-Nr.
91161-71-6
Englisch Name:
Terbinafine
Synonyma:
LAMISIL;(E)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine;TDT 067;Terbinex;sf-86-327;TERBINAFINE;rerbinafine;Terbinafine-d3;(E)-Terbinafine;Terbinafine USP/EP/BP
CBNumber:
CB6201128
Summenformel:
C21H25N
Molgewicht:
291.43
MOL-Datei:
91161-71-6.mol

Terbinafine Eigenschaften

Schmelzpunkt:
203-205 °C
Siedepunkt:
417.9±33.0 °C(Predicted)
Dichte
1.007±0.06 g/cm3(Predicted)
Dampfdruck
0Pa at 25℃
storage temp. 
2-8°C
L?slichkeit
soluble in Methanol
Aggregatzustand
powder to crystal
pka
6.92±0.50(Predicted)
Farbe
White to Light yellow
LogP
3.3 at 37℃ and pH7
CAS Datenbank
91161-71-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
HS Code  2921450090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Terbinafine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Verwenden

Terbinafine (Lamisil) is a second-generation allylamine that is related to naftifine; however, it is 10 to 100 times more potent in vitro. It is fungicidal, whereas griseofulvin, ketoconazole, itraconazole, and other azole derivatives are all fungistatic. Because it is fungicidal, duration of therapy is shorter, and relapse rates are less than with other oral or topical therapies. Terbinafine acts by inhibiting squalene epoxidase and thereby decreasing synthesis of ergosterol, an essential component of fungal cell membranes. It is highly lipophilic and concentrates in the stratum corneum, sebum, and hair follicles. Slightly better cure rates are attained with b.i.d. than with daily dosing.
Lamisil (Novartis) Tablets

Indications

Terbinafine (Lamisil) is a second-generation allylamine that is related to naftifine; however, it is 10 to 100 times more potent in vitro. It is fungicidal, whereas griseofulvin, ketoconazole, itraconazole, and other azole derivatives are all fungistatic. Because it is fungicidal, duration of therapy is shorter, and relapse rates are less than with other oral or topical therapies.
Terbinafine acts by inhibiting squalene epoxidase and thereby decreasing synthesis of ergosterol, an essential component of fungal cell membranes. It is highly lipophilic and concentrates in the stratum corneum, sebum, and hair follicles. Slightly better cure rates are attained with b.i.d. than with daily dosing.

Definition

ChEBI: A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the t eatment of skin and nail infections.

Antimicrobial activity

Terbinafine is active against a wide range of pathogenic fungi, including dermatophytes (Epidermophyton, Microsporum and Trichophyton spp.), various Candida spp., Aspergillus spp., some dimorphic fungi (Blastomyces dermatitidis, Histoplasma capsulatum and Sporothrix schenckii) and many dematiaceous fungi.

Acquired resistance

Resistance has not been reported.

Pharmazeutische Anwendungen

A synthetic allylamine available as the hydrochloride for oral and topical administration.

Pharmakokinetik

Oral absorption: 70–80%
Cmax 250 mg oral: c. 1 mg/L after 2 h
Plasma half-life: c. 17 h
Volume of distribution: 1000 L
Plasma protein binding: >99%
Blood concentrations increase in proportion to dosage. It is lipophilic and is rapidly and extensively distributed to body tissues. It reaches the stratum corneum by diffusion through the dermis and epidermis, and secretion in sebum. Diffusion from the nail bed is the major factor in its rapid penetration of nails. It is metabolized by the liver and the inactive metabolites are mostly excreted in the urine. The elimination half-life is prolonged in patients with hepatic or renal impairment.

Clinical Use

Terbinafine hydrochloride can be used in Tinea pedis, tinea corporis, tinea cruris, tinea capitis, Onychomycosis caused by dermatophytes.

Nebenwirkungen

These include abdominal discomfort, loss of appetite, nausea, diarrhea, headache, impairment of taste, rash and urticaria. Serious skin reactions, including Stevens– Johnson syndrome, and rare hepatotoxic reactions, including jaundice, cholestasis and hepatitis, are occasionally encountered.

Terbinafine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Terbinafine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 324)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5975 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Chengdu Aupone Pharmaceutical Co.Ltd.
+86-28-+86-28-87843998-6060-6060 +8618631098571
lijiaqi@aupone.com China 54 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2691 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Jinan Jianfeng Chemical Co., Ltd
0531-88110457; +8615562555968
info@pharmachemm.com China 251 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 491 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58

91161-71-6()Verwandte Suche:


  • trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine
  • (e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamine
  • 6-dimethyl-2-hepten-4-ynyl)-n-methyl-n-((e)-1-naphthalenemethanamin
  • sf-86-327
  • TERBINAFINE
  • 1-Naphthalenemethanamine, N-(2E)-6,6-dimethyl-2-hepten-4-ynyl-N-methyl-
  • (E)-N-(6,6-I)imethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine
  • rerbinafine
  • (E)-6,6,N-Trimethyl-N-(1-naphtylmethyl)-2-heptene-4-yne-1-amine
  • (E)-Terbinafine
  • 1-[[[(E)-6,6-Dimethyl-2-heptene-4-ynyl](methyl)amino]methyl]naphthalene
  • N-[(E)-6,6-Dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine
  • N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
  • 1-Naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-
  • ( E)-N-Methyl-N-(1-naphthylMethyl)-6,6-diMethyl-hept-2-en-4-inyl-1-aMine
  • N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine hydrochloride
  • Terbinafine-d3
  • Terbinafine(LaMisil, Terbinex)
  • [(2E)-6,6-diMethylhept-2-en-4-yn-1-yl](Methyl)(naphthalen-1-ylMethyl)aMine
  • N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine
  • (6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphthalen-1-ylmethyl-amine
  • Terbinafine Impurity 1
  • TERBINAFINETERBINAFINE
  • (E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine
  • TDT 067
  • Terbinex
  • Terbinafine USP/EP/BP
  • (2E) N,6,6-Trimethyl-N-(napthalen-1-ylmethyl)hept-2-en-4-yn-1-amine (Terbinafine Base)
  • Terbinafine (10mM in DMSO)
  • TerbinafineQ: What is Terbinafine Q: What is the CAS Number of Terbinafine Q: What is the storage condition of Terbinafine Q: What are the applications of Terbinafine
  • LAMISIL
  • (E)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine
  • Than naphthalene Finn
  • 91161-71-6
  • 99161-71-6
  • C21H25N
  • C21H26ClN
  • C21N25N
  • Inhibitors
  • Active Pharmaceutical Ingredients
  • Terbinafine
  • API
Copyright 2019 ? ChemicalBook. All rights reserved