Ziprasidone
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- CAS-Nr.
- 146939-27-7
- Englisch Name:
- Ziprasidone
- Synonyma:
- ZIPRASIDONE-D8;Geodon;CP 88059;Ziprasidone;Ziprasidone HBr;CP-88059：CP-88059-1;Ziprasidone solution;Ziprasidone Free Base;Ziprasidone USP/EP/BP;Hydrochloric acid(base)
- CBNumber:
- CB6167417
- Summenformel:
- C21H21ClN4OS
- Molgewicht:
- 412.94
- MOL-Datei:
- 146939-27-7.mol
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Ziprasidone Eigenschaften
- Schmelzpunkt:
- 213-215°C
- Siedepunkt:
- 554.8±50.0 °C(Predicted)
- Dichte
- 1.369±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 13.34±0.20(Predicted)
- Farbe
- Brown to Dark Brown
- Merck
- 14,10171
- CAS Datenbank
- 146939-27-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H373 |
Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P272 |
Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P314 |
Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen. |
| P333+P313 |
Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Ziprasidone Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Tan Solid
Verwenden
Labelled Ziprasidone, which is used as an antipsychotic. Combined serotonin (5HT2) and dopamine (D2) receptor antagonist.
Definition
ChEBI: A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.
Biologische Funktion
"Ziprasidone is chemically similar to risperidone but with a substitution of piperzinyl and benzisothiazole for
piperidinyl and benzisoxazole and with minor aromatic modification. Like risperidone, ziprasidone is a high-affinity
antagonist at 5-HT2A/C and D2 receptors as well as at adrenergic α1/α2 and histamine H1 receptors. Moreover,
ziprasidone can activate 5-HT1A receptors that regulate dopaminergic neurotransmission in brain regions
involved in critical cognitive functions. Thus, in addition to D2 partial agonism, 5-HT1A agonism is now
thought to be an important pharmacological property for atypical antipsychotic drug efficacy.
Allgemeine Beschreibung
Ziprasidone (Geodon, a benzisothiazolpiprazinylindolonederivative) also has the structuralfeatures of a hybrid molecule between a butyrophenone antipsychoticand a trazodone-like antidepressant. It is highlymetabolized to four major metabolites, only one of which, Smethyldihydroziprasidone,likely contributes to its clinical activity. In humans, less than 5% of the dose isexcreted unchanged. Reduction by aldehyde oxidase accountsfor about 66% of ziprasidone metabolism; two oxidative pathwaysinvolving hepatic CYP3A4 account for the remainder.
Mechanism of action
Ziprasidone
(half-life, 6 hours) has an oral bioavailability of approximately 60%, which can be enhanced in the presence of fatty
foods. It is extensively metabolized (<5% excreted unchanged) by aldehyde oxidase, which results in reductive
cleavage of the S–N bond, and then by S-methylation. Ziprasidone also can undergo CYP3A4-catalyzed
N-dealkylation and S-oxidation.
Ziprasidone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ziprasidone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 222)Lieferanten
146939-27-7()Verwandte Suche:
- Ziprasidone
- CP-88059：CP-88059-1
- 1,2-Benzisothiazole, 3-(1-piperazinyl)-, monohydrochlorideH-indol-2-one, 6-chloro-5-(2-chloroethyl)-1,3-dihydro
- 5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one
- Ziprasidone HBr
- 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-2,3-dihydro-1H-indol-2-one
- Ziprasidone solution
- 5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one
- 5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl-d8]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one
- 2H-Indol-2-one, 5-2-4-(1,2-benzisothiazol-3-yl)-1-piperazinylethyl-6-chloro-1,3-dihydro-
- ZIPRASIDONE: ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE
- CP 88059
- Hydrochloric acid(base)
- Ziprasidone for system suitability 1 CRS
- Ziprasidone for system suitability 2 CRS
- Ziprasidone Free Base
- Ziprasidone USP/EP/BP
- ZIPRASIDONE-D8
- Geodon
- Ziprasidone in Methanol:DMSO=3:1
- 146939-27-7
- C21H13D8ClN4OS
- C21H13ClN4OSD8
- Heterocycles
- Active Pharmaceutical Ingredients
- Geodon, Zeldox
- Other APIs
- API
- Intermediates & Fine Chemicals
- Isotope Labeled Compounds
- Pharmaceuticals
- Isotope Labelled Compounds
- Sulfur & Selenium Compounds
