(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE
|
|
|
- CAS-Nr.
- 6989-98-6
- Englisch Name:
- (+)-TUBOCURARINE CHLORIDE PENTAHYDRATE
- Synonyma:
- TUBOCURARINE CHLORIDE;Tubarine pentahydrate.;Tubocurarin-dichloride;TUBOCURARINE CHLORIDE 98%;Tubocurarine hydroehloride;Tubocurarine Chloride (250 mg);Tubocurarine Chloride (1702008);Tubocurarine chloride,98.0-102.0%;Tubocurarin-dichloride, Pentahydrat;TubocurarineChloridePentahydrate>
- CBNumber:
- CB5737132
- Summenformel:
- C37H44Cl2N2O7
- Molgewicht:
- 699.67
- MOL-Datei:
- 6989-98-6.mol
|
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE Eigenschaften
- Schmelzpunkt:
- 275-280 °C (dec.)(lit.)
- Dichte
- 1.2074 (rough estimate)
- Brechungsindex
- 193 ° (C=1, H2O)
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: soluble50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow
- Aggregatzustand
- Crystalline powder
- Farbe
- White to Light yellow to Light orange
- Optische Aktivit?t
- [α]20/D +195±5°, c = 0.5% in H2O
- Wasserl?slichkeit
- Soluble in water to 50mg/ml, with warming as needed. Also soluble in ethanol or methanol
- Sensitive
- Air Sensitive
- Merck
- 14,9807
- BRN
- 3896374
- Stabilit?t:
- Hygroscopic
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
|
|
| R-S?tze: |
25 |
|
|
| S-S?tze: |
45-36/37/39-22 |
|
|
| RIDADR |
UN 1544 6.1/PG 3 |
|
|
| WGK Germany |
3 |
|
|
| RTECS-Nr. |
YO5100000 |
|
|
| F |
10-23 |
|
|
| HazardClass |
6.1 |
|
|
| PackingGroup |
III |
|
|
| HS Code |
29349990 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-S?tze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Beschreibung
Tubocurarine chloride is the only naturally occurring neuromuscular
blocking agent. It is derived from the bark of the South American plant
chondrodendron tomentosum, which has been used for centuries by South
American Indians as an arrow poison. I t was the first non-depolarising
neuromuscular blocking agent to be used in humans. I t has a marked
propensity to produce histamine release and thus hypotension, with possibly
a compensatory tachycardia. Historically, tubocurarine, alcuronium and
gallamine have been used in clinical practice, but they are no longer available
in the UK. A lcuronium chloride is a semisynthetic derivative of toxiferin, an
alkaloid of calabash curare. Gallamine triethiodide is a trisquaternary amine.
It was first used in France in 1948. The only recent use of gallamine in the UK
was as a small pretreatment dose (10 mg) before suxamethonium.
Chemische Eigenschaften
white to slightly yellowish powder
Verwenden
antibacterial
Allgemeine Beschreibung
Tubocurarine chloride,( )-tubocurarine chloride hydrochloride pentahydrate, isprepared from crude curare by a process of purification andcrystallization. Tubocurarine chloride occurs as a white oryellowish white to grayish white, odorless, crystalline powderthat is soluble in water. Aqueous solutions of it are stableto heat sterilization.
The structural formula for (+)-tubocurarine was longthought to be that of Ia (see structure diagram). Throughthe work of Everett et al.,the structure is now knownto be that of Ib. The monoquaternary nature of Ib thusrevealed has caused some reassessment of thinking concerningthe theoretical basis for the blocking action, becauseall had previously assumed a diquaternary structure(i.e., Ia). Nevertheless, this does not negate the earlierconclusions that a diquaternary nature of the molecule provides better blocking action than does a monoquaternarynature (e.g., Ib is approximately fourfold lesspotent than dimethyl tubocurarine iodide). Further, (+)-isotubocurarine chloride (Ic) has twice the activity of Ib inthe particular test used.
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 92)Lieferanten
6989-98-6()Verwandte Suche:
- Tubocurarin-dichloride
- Tubocurarine Chloride (250 mg)
- Tubocurarine hydrochloride pentahydrate
- dichloride,pentahydrate,(+)-tubocurarin
- TUBOCURARINE CHLORIDE
- Tubocurarine hydroehloride
- (+)-TUBOCURARINE CHLORIDE PENTAHYDRATE
- D-TUBOCURARINE CHLORIDE PENTAHYDRATE
- (+)-TUBOCURARINE CHLORIDE MUSCLE RELAXAN T
- Tubarine pentahydrate.
- Tubocurarin-dichloride, Pentahydrat
- TUBOCURARINE CHLORIDE 98%
- Tubocurarine chloride,98.0-102.0%
- D-Tubocurarine chloride pentahydrate 97%
- TubocurarineChloridePentahydrate>
- (+)-Tubocurarine Chloride Hydrochloride Pentahydrate
- (+)-Tubocurarine Chloride Pentahydrate
- Tubocurarine Chloride (1702008)
- D Tubocurarine chloride pentahydrate,DTubocurarine chloride pentahydrate
- 6989-98-6
- C37H52Cl2N2O11
- C37H41N2O6ClHCl5H2O
- C37H41ClN2O6HCl5H2O
- C37H42Cl2N2O65H2O
- Biochemicals and Reagents
- BioChemical
- Chiral Building Blocks
- Asymmetric Synthesis
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Type
- Enzyme Inhibitors
- Complex Molecules
- Other
- NIZIN
- Complex MoleculesEnzyme Inhibitors
- Asymmetric Synthesis
- Chiral Building Blocks
- Enzyme Inhibitors by Type
- Other
- Alkaloids
- Biochemistry
- Isoquinoline Alkaloids
