2'-O-Methyladenosine
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- CAS-Nr.
- 2140-79-6
- Englisch Name:
- 2'-O-Methyladenosine
- Synonyma:
- (2R,3R,4R,5R)-5-(6-AMino-9H-purin-9-yl)-2-(hydroxyMethyl)-4-Methoxytetrahydrofuran-3-ol;AMI;cordysinin B;OMe-rA;2'-OMe-A;2'-OMe A;2'-OMe-rA;2'-OMe-Ar;2'-OMe-Ar;2'-O-Me-dA
- CBNumber:
- CB5476675
- Summenformel:
- C11H15N5O4
- Molgewicht:
- 281.27
- MOL-Datei:
- 2140-79-6.mol
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2'-O-Methyladenosine Eigenschaften
- Schmelzpunkt:
- 200-202 C
- Siedepunkt:
- 623.8±65.0 °C(Predicted)
- Dichte
- 1.84±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
- Aggregatzustand
- Powder
- pka
- 13.13±0.70(Predicted)
- Farbe
- White to Off-white
- Wasserl?slichkeit
- Soluble in water.
- maximale Wellenl?nge (λmax)
- 259nm(H2O)(lit.)
- InChI
- InChI=1S/C11H15N5O4/c1-19-8-7(18)5(2-17)20-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
- InChIKey
- FPUGCISOLXNPPC-YGHVBYMHSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](OC)[C@@H]1O
- CAS Datenbank
- 2140-79-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2'-O-Methyladenosine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2'-O-Methyladenosine (Cordysinin B) is a member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis. It has a role as a fungal metabolite. It is a member of adenosines and an ether. It derives from an adenosine. analogue with antiviral properties, starting material for 2'-O'-methyl nucleotides. Potential metabolite of 2'-O-Me-cAMP.
Chemische Eigenschaften
White Solid
Verwenden
2'-O-Methyladenosine is an analog of adenosine used to prepare nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
Definition
2'-O-Methyladenosine is nucleoside modification in which a methyl group is added to the 2' hydroxyl of the ribose moiety of adenosine.
Allgemeine Beschreibung
The 2'-O-Methyladenosine (Am) was showed to be the first nucleotide adjacent to the N
7-methylguanosine (m
7G) cap and it can be further modified at the N
6 position by methylation to generate N6,2’-O-dimethyladenosine (m
6Am) (92% chance of being modified), where the structure of m
7G5'ppp5'm
6AmpNp comprises 20–30% of all the structures[1]. The 2'-O-methyladenosine (Am) modification displaying the lowest level in tumor tissues[2].
Biologische Aktivit?t
2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities.
2'-O-Methyladenosine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2'-O-Methyladenosine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 270)Lieferanten
2140-79-6()Verwandte Suche:
- 2'-O-Methyladdenosine
- 2'-O-Methyl-D-adenosine
- 5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
- 2'-O-METHYLADENOSINE
- 2'-OMe-A
- (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
- (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-methoxy-2-methylol-tetrahydrofuran-3-ol
- (2R,3R,4R,5R)-5-(6-azanylpurin-9-yl)-2-(hydroxymethyl)-4-methoxy-oxolan-3-ol
- 2'-OMe Adenosine
- 2'-OMe-rA
- 2'-O-Methyladenosine, 99.0%
- 2'-O-Me-Ado
- -O-Methyladenosine
- 2-Amino-N6-(dimethylaminomethylidene)-N2-isobutyryl-2&rsquo
- (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxy-tetrahydrofuran-3-ol
- 2'-OMe-Ar
- 2'-O-Methyladenosine>
- Adenosine, 2'-O-methyl-
- 2'-O-Methyladenosine USP/EP/BP
- AMI
- (2R,3R,4R,5R)-5-(6-AMino-9H-purin-9-yl)-2-(hydroxyMethyl)-4-Methoxytetrahydrofuran-3-ol
- cordysinin B
- 2’-O-Methyl adenosine,RNA modified nucleoside Am
- RNA modified nucleoside Am
- -O-Methyladenosine
- OMe-rA
- 2'-O-Methyladenosine
- 2'-OMe Adenosine
- 2'-O-Me-dA
- 2'-OMe-Ar
- 2 ' - 0 -Methyladenosine
- 2'-OMe A
- 2140-79-6
- Nucleosides, Nucleotides, Oligonucleotides
- Nucleoside Analogs
- BioChemical
- Biochemicals and Reagents
- Biochemicals and Reagents
- Nucleoside Analogs
- Nucleosides, Nucleotides, Oligonucleotides
- Bases & Related Reagents
- Carbohydrates & Derivatives
- Heterocycles
- Nucleotides
- Nucleosides
- Modified(deoxy)nucleoside
- Nucleosides-2'-OMe Nucleosides