3-Methyl-3H-adenin
|
|
|
- CAS-Nr.
- 5142-23-4
- Bezeichnung:
- 3-Methyl-3H-adenin
- Englisch Name:
- 3-METHYLADENINE
- Synonyma:
- 109723;NSC 66389;NSC-63889;NSC 66389,3-M;3-Methyl-6-am;NSC 66389,3-MA;3-methyl-adenin;3-METHYLADENINE;N3-Methyladenine;Adenine, 3-methyl-
- CBNumber:
- CB9307216
- Summenformel:
- C6H7N5
- Molgewicht:
- 149.15
- MOL-Datei:
- 5142-23-4.mol
|
3-Methyl-3H-adenin Eigenschaften
- Schmelzpunkt:
- ~300 °C (dec.)(lit.)
- Siedepunkt:
- 240℃
- Dichte
- 1.60
- Brechungsindex
- 1.8070 (estimate)
- Flammpunkt:
- 99℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
- pka
- 6.77±0.20(Predicted)
- Aggregatzustand
- Powder
- Farbe
- White
- BRN
- 146087
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
|
|
| R-S?tze: |
22 |
|
|
| S-S?tze: |
24/25 |
|
|
| WGK Germany |
3 |
|
|
| RTECS-Nr. |
AU6520000 |
|
|
| HS Code |
29335990 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
|
| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P403 |
An einem gut belüfteten Ort aufbewahren. |
|
3-Methyl-3H-adenin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Autophagy is a multi-
step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-
kinase (PI3K), is a key regulator of autophagy. 3-
Methyladenine (3-
MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-
MA inhibits protein degradation in rat hepatocytes by 65%. 3-
MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.
Chemische Eigenschaften
White powder
Verwenden
3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
Definition
ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.
Allgemeine Beschreibung
A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC
50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos.
440202 and
440204) and Wortmannin (Cat. No.
681675)
3-Methyl-3H-adenin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Methyl-3H-adenin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 273)Lieferanten
5142-23-4(3-Methyl-3H-adenin)Verwandte Suche:
- 3H-Purin-6-amine, 3-methyl-
- 3-methyl-3h-purin-6-amin
- 3-Methyl-3H-purin-6-amine
- 3-methyl-adenin
- Adenine, 3-methyl-
- 3-METHYLADENINE
- 3-methyl-3H-adenine
- 6-AMINO-3-METHYLPURINE
- 3-Methyladenine, 90+%, pure
- 3-Methyladenine, pure
- 3-Methyl-6-amino-3H-purine
- 3-Methyladenine6-Amino-3-methylpurine
- 3-Methyladenine, pure, 90+%
- 3-Methyl-6-aminopurine
- N3-Methyladenine
- NSC 66389
- 3-MA (3-Methyl adenine)
- 3-methyladenine,3MA
- NSC 66389,3-MA
- 3-Methyladenine, GC 90+%
- NSC 66389,3-M
- 6-Amino-3-methylpurine 3-Methyladenine
- Autophagy Inhibitor
- 3-Methyladenine, >=98%
- Autophagy Inhibitor, 3-MA
- Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem
- 109723
- 3-methylpurin-6-amine
- Methyladenine Methyladenine
- NSC-63889
- 3-METHYLADENINE USP/EP/BP
- N3-Methyladenine/NSC 66389
- 3-Methyl-6-am
- 5142-23-4
- Building Blocks
- Biochemicals and Reagents
- BioChemical
- Heterocyclic Building Blocks
- Purines
- Nucleoside Analogs
- Nucleosides, Nucleotides, Oligonucleotides
- Akt
- mTOR
- PI3K
- Amines
- Bases & Related Reagents
- Heterocycles
- Inhibitors
- Nucleotides
