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Digitoxin

Digitoxin Struktur
71-63-6
CAS-Nr.
71-63-6
Bezeichnung:
Digitoxin
Englisch Name:
Digitoxin
Synonyma:
Digitoxoside;Cardigin;DIGITALIN;digitoxinum;Digitogenin;CRYSTODIGIN;digicor;Digimed;Ditaven;Natigal
CBNumber:
CB5194029
Summenformel:
C41H64O13
Molgewicht:
764.94
MOL-Datei:
71-63-6.mol

Digitoxin Eigenschaften

Schmelzpunkt:
240 °C (dec.)(lit.)
alpha 
D20 +4.8° (c = 1.2 in dioxane)
Siedepunkt:
654.47°C (rough estimate)
Dichte
1.0971 (rough estimate)
Brechungsindex
17 ° (C=2, CHCl3)
Flammpunkt:
9℃
storage temp. 
2-8°C
L?slichkeit
chloroform: soluble
Aggregatzustand
powder
pka
13.50±0.70(Predicted)
Farbe
White
Wasserl?slichkeit
3.9mg/L(25 ºC)
Merck 
14,3163
BRN 
76678
Stabilit?t:
Hygroscopic
EPA chemische Informationen
Digitoxin (71-63-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T,F
R-S?tze: 23/25-33-39/23/24/25-23/24/25-11
S-S?tze: 45-36/37-16
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS-Nr. IH2275000
3-10
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  II
HS Code  2938900000
Giftige Stoffe Daten 71-63-6(Hazardous Substances Data)
Toxizit?t LD50 in guinea pigs, cats (mg/kg): 60.0, 0.18 orally (Foerster)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizit?t oral Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H331 Giftig bei Einatmen. Akute Toxizit?t inhalativ Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P314 Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen.

Digitoxin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R23/25:Giftig beim Einatmen und Verschlucken.
R33:Gefahr kumulativer Wirkungen.

S-S?tze Betriebsanweisung:

S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Digitoxin is the most powerful and reliable of the glucosides which have been extracted from digitalis leave. It is a cardiac glycoside (CG). It is a cardiotonic drug, which exhibits cardiac and anti-cancer properties. Digitoxin inhibits nuclear factor kappa B (NF-κB) signaling. It is used to treat congestive heart failure and cardiac arrhythmia. Digitoxin prevents microtubule formation.

Chemische Eigenschaften

White Solid

Verwenden

Digitoxin has been used as a labeled drugs for binding sites on human serum albumin (HSA). It has also been used to test its anti-transmissible gastroenteritis virus (TGEV) activity.

Indications

Digitoxin (Dig) is an FDA approved drug for the treatment of cardiac disease.
Digitoxin is used for the treatment of heart failure, especially in people with impaired kidney function. It is also used to treat certain kinds of heart arrhythmia, such as atrial fibrillation.
Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It also helps the heart work better and control heart rate. Digoxin may be used after a heart attack. This medication comes in various forms: tablet, capsule, or pediatric elixir (liquid). It is available under the brand names Lanoxin, Cardoxin, Digitek, Digox, and Lanoxicaps.

Allgemeine Beschreibung

Odorless white or pale buff microcrystalline powder. Used as a cardiotonic drug.

Health Hazard

Material is bioactive and capable of causing cardiac arrythmias and electrolyte imbalances that may be fatal. Death is due to ventricular fibrillation or cardiac standstill. Material has a high toxicity hazard rating; it may cause death or permanent injury after a very short exposure. It is classified as super toxic; an estimated single lethal dose is 3-10 mg.

Brandgefahr

When heated to decomposition, DIGITOXIN emits acrid smoke and irritating fumes.

Sicherheitsprofil

A deadly poison by most routes. Human systemic effects: arrhythmias, cardiomyopathy, EKG changes, nausea or vomiting, paresthesia, pulse rate increase, thrombocytopenia. Human reproductive effects by ingestion: reduced viability of newborn. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes. See also DIGITALIS.

l?uterung methode

Digitoxin crystallises from MeOH, aqueous EtOH with 0.5 to 1 H2O and from H2O as the dihydrate. It also crystallises from CHCl3/Et2O as anhydrous crystals. The hydrate dehydrates at 120o/vacuum. Its solubility is 2.5% in CHCl3, 1.7% in EtOH, 0.25% in EtOAc, and 0.001% in H2O; and has E1cm 202.5 at 219-220nm (50% EtOH). [Stoll et al. Helv Chim Acta 37 1134 1954, Demoen & Janssen J Am Pharm Assoc 42 635 1953, Beilstein 18 IV 1478.]

Digitoxin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Digitoxin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 222)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Antai Fine Chemical Technology Co.,Limited
18503026267
info@antaichem.com CHINA 9636 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58

71-63-6(Digitoxin)Verwandte Suche:


  • (3beta,5beta)-hexopyranosyl)oxy]-14-hydroxy
  • (3beta,5beta)-y)-14-hydroxy
  • .4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3beta,5beta)-
  • .4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.->
  • 3-((2,6-Dideoxy-4-O-[2,6-dideoxy-4-O-(2,6-dideoxyhexopyranosyl)hexopyranosyl]hexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide
  • digicor
  • Digilong
  • Digimed
  • digipural
  • Digisidin
  • digitalin,crystalline
  • Digitaline cristallisee
  • Digitaline nativelle
  • digitalinecristallisee
  • digitalinenativelle
  • Digitalinum verum
  • digitalinumverum
  • digitoksim
  • Digitoksin
  • Digitophyllin
  • Digitoxigenin tridigitoxoside
  • digitoxigenin-tridigitoxosid
  • digitoxigenintridigitoxoside
  • Digitrin
  • Digtoxoside
  • Ditaven
  • droxycard-20(22)-enolide
  • Glucodigin
  • Lanatoxin
  • mono-digitoxid
  • monodigitoxoside
  • mono-glycocard
  • Myodigin
  • Natigal
  • Purodigin
  • Purodigin, crystalline
  • ta-d-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-14-hy
  • Tardigal
  • Tri-digitoxoside
  • Unidigin
  • DIGITOXIN CRYSTALLINE
  • Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-
  • hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-
  • hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-
  • hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
  • (3,5)-3-[(O-2,6-Dideoxy--D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy--D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy--D-ribo-hexopyranosyl)oxyl]-14-hydroxycard-20(22)-enolide
  • Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
  • Digitoxin (8CI)
  • Digitoxoside (7CI)
  • NSC 7529
  • Tradigal
  • (3b,5b)-3-[(O-2,6-Dideoxy-b-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxyl]-14-hydroxycard-20(22)-enolide
  • Card-20(22)-enolide, 3-(O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1?4)-O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl)oxy-14-hydroxy-, (3.beta.,5.beta.)-
  • 5β,20(22)-cardenolide-3β,14-diol-3-(o-2,6-dideoxy-β-d-ribo-hexopyranosyl-[1→4]-o-2,6-dideoxy-β-d-ribo-hexopyranosyl-[1→4]-2,6-dideoxy-β-d-ribo-hexopyranosyl)oxy
  • DIGITOXIN,USP
  • DIGITOXIN(P)
  • 3-[(o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.4)-card-20(22)-enolid
  • 4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3beta,5beta)-
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