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Clonidinhydrochlorid

Clonidine hydrochloride Struktur
4205-91-8
CAS-Nr.
4205-91-8
Bezeichnung:
Clonidinhydrochlorid
Englisch Name:
Clonidine hydrochloride
Synonyma:
CLONIDINE HCL;dcai;2-(2,6-DICHLOROANILINO)-2-IMIDAZOLINE HYDROCHLORIDE;DIXARIT;hemiton;Neuclon;atensina;capresin;clofelin;haemiton
CBNumber:
CB3763159
Summenformel:
C9H10Cl3N3
Molgewicht:
266.55
MOL-Datei:
4205-91-8.mol

Clonidinhydrochlorid Eigenschaften

Schmelzpunkt:
312 °C
storage temp. 
2-8°C
L?slichkeit
H2O: 50 mg/mL, clear, colorless
Aggregatzustand
solid
Farbe
white
PH
pH(50g/l, 25℃) : 3.5~6.0
Wasserl?slichkeit
Soluble in water (50 mg/ml), DMSO (75 mM), methanol, chloroform (slightly), and dehydrated alcohol.
Merck 
14,2390
BRN 
4163525
BCS Class
1 (LogP), 3 (CLogP)
Stabilit?t:
Hygroscopic
InChI
InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
InChIKey
GLEWMLFXCSBZLK-UHFFFAOYSA-N
SMILES
C1(=C(Cl)C=CC=C1Cl)NC1=NCCN1.Cl
CAS Datenbank
4205-91-8(CAS DataBase Reference)
EPA chemische Informationen
1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, hydrochloride (1:1) (4205-91-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T+
R-S?tze: 25-26
S-S?tze: 22-26-28-36/37/39-45
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS-Nr. NJ2490000
10
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933290000
Toxizit?t LD50 in mice, rats (mg/kg): 328, 270 orally; 18, 29 i.v. (Walland)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H330 Lebensgefahr bei Einatmen. Akute Toxizit?t inhalativ Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P403+P233 An einem gut belüfteten Ort aufbewahren. Beh?lter dicht verschlossen halten.

Clonidinhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R26:Sehr giftig beim Einatmen.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Chemische Eigenschaften

White Solid

Verwenden

Clonidine hydrochloride tablets are indicated in the treatment of hypertension. It has found new uses, including treatment of some types of neuropathic pain, opioid detoxification, sleep hyperhidrosis, anaesthetic use, and off-label, to counter the side effects of stimulant medications such as methylphenidate or amphetamine. It is becoming a more accepted treatment for insomnia, as well as for relief of menopausal symptoms. Clonidine(4205-91-8) is increasingly used in conjunction with stimulants to treat attention-deficit hyperactivity disorder (ADHD).

Allgemeine Beschreibung

Clonidine hydrochloride, 2-[(2,6-dichlorophenyl)imino]imidazolidine monohydrochloride(Catapres), was the first antihypertensive known to acton the CNS. It was synthesized in 1962 as a derivativeof the known -sympathomimetic drugs naphazoline andtolazoline, potential nasal vasoconstrictors, but instead itproved to be effective in the treatment of mild-to-severe hypertension.Clonidine hydrochloride acts by both peripheral andcentral mechanisms in the body to affect blood pressure. Itstimulates the peripheral -adrenergic receptors to producevasoconstriction, resulting in a brief period of hypertension.

Biologische Aktivit?t

Prototypical I 1 imidazoline receptor ligand. α 2 -adrenergic receptor agonist. Antihypertensive.

Clinical Use

Clonidine hydrochloride acts by both peripheral andcentral mechanisms in the body to affect blood pressure. Itstimulates the peripheral α-adrenergic receptors to producevasoconstriction, resulting in a brief period of hypertension.Clonidine hydrochloride acts centrally to inhibitthe sympathetic tone and cause hypotension that is ofmuch longer duration than the initial hypertensive effect.Administration of clonidine hydrochloride thus produces abiphasic change in blood pressure, beginning with a briefhypertensive effect and followed by a hypotensive effectthat persists for about 4 hours. This biphasic response isaltered by dose only. Larger doses produce a greater hypertensiveeffect and delay the onset of the hypotensiveproperties of the drug. Clonidine hydrochloride acts on 2-adrenoreceptors located in the hindbrain to produce itshypotensive action. Clonidine hydrochloride also acts centrallyto cause bradycardia and to reduce plasma levels ofrenin. Sensitization of baroreceptor pathways in the CNSappears to be responsible for the bradycardia transmittedby way of the vagus nerve. The central mechanism that resultsin decreased plasma renin is not known, however.The hypotensive properties of clonidine in animals can beblocked by applying -adrenergic blocking agents directlyto the brain.

l?uterung methode

This antihypertensive is recrystallised from EtOH/Et2O and dried in a vacuum (solubility in H2O is 5%). The free base has m 124-125o and is recrystallised from hexane. [Jen et al. J Med Chem 18 90 1975, NMR: Jackman & Jen J Am Chem Soc 97 2811 1975.]

Clonidinhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Clonidinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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4205-91-8(Clonidinhydrochlorid)Verwandte Suche:


  • CLONIDINE HYDROCHLORIDE
  • DIXARIT
  • 2-[2,6-DICHLOROANILINE]-2-IMIDAZOLINE HYDROCHLORIDE
  • 2-(2,6-DICHLOROANILINO)-2-IMIDAZOLINE, HCL
  • 2-(2,6-DICHLOROPHENYLAMINO)-2-IMIDAZOLINE HYDROCHLORIDE
  • katapresan
  • klophelin
  • n-(2,6-dichlorophenyl)-4,5-dihydro-1h-imidazol-2-aminmonohydrochloride
  • normopresan
  • TIMTEC-BB SBB003065
  • 2-((2,6-dichlorophenyl)imino)imidazolidinemonohydrochloride
  • 2-(2,6-dichloroanilino)-2-imidazolinmonohydrochloride
  • 2-(2,6-dichlorophenylamino)-2-imidazolinhydrochlorid
  • 2,6-dichloro-n-2-imidazolidinylidene-benzenaminhydrochloride
  • atensina
  • capresin
  • chlophazolin
  • clofelin
  • clonidinemonohydrochloride
  • haemiton
  • hemiton
  • isoglaucon
  • Clonidine Hydrochloride BP2000/USP25
  • ClonidineHclC9H9C12N3.HCL
  • 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, monohydrochloride
  • CLONIDINEHYDROCHLORIDE,USP
  • 2-IMIDAZOLONE,2-(2,6-DICHLOROANILINO)-,MONOHYDROCHLORIDE
  • Clomiding Hydrochloride
  • ClonidineHydrochlorideUsp27
  • NormopresanClonidine monohydrochloride
  • Clonidine hydrochlor
  • Clonidine Hydrochloride (200 mg)
  • Neuclon
  • Clonidine Hydrochloride 2-(2,6-Dichlorophenylamino)-2-imidazoline Hydrochloride
  • N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine,hydrochloride (1:1)
  • catapresan
  • Clonidine hydrochloride CRS
  • 2-(2,6-Dichloroanilino)-2-imidazoline Hydrochloride >
  • 2,6-dichloro-N-(imidazolidin-2-ylidene)aniline hydrochloride
  • N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine HCl
  • Clonidine hydrochloride USP/EP/BP
  • Clonidine HydrochlorideQ: What is Clonidine Hydrochloride Q: What is the CAS Number of Clonidine Hydrochloride Q: What is the storage condition of Clonidine Hydrochloride Q: What are the applications of Clonidine Hydrochloride
  • Clonidine Hydrochloride (1140407)
  • CLONIDINE HCL
  • 2-(2,6-DICHLOROANILINO)-2-IMIDAZOLINE HYDROCHLORIDE
  • dcai
  • Clonidine HCl|||Catapres
  • Clonidine hydrochloride in methanol
  • C11686810 ClonidinEhydrochloride
  • 4205-91-8
  • C9H10Cl3N3
  • C9H9Cl2N3ClH
  • C9H9Cl12N3HCl
  • C9H9Cl2N3HCl
  • C9H9CI2N3HCl
  • alpha2-adrenoceptor agonist; I1 imidazoline binding site ligand.
  • CATAPRES
  • Other APIs
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