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ChemicalBook CAS DataBase List LINOLENIC ACID ETHYL ESTER
1191-41-9

LINOLENIC ACID ETHYL ESTER synthesis

3synthesis methods
-

Yield:1191-41-9 99%

Reaction Conditions:

with immobilized Candida antarctica Lipase B in neat (no solvent) at 60; for 4 h;Green chemistry;Enzymatic reaction;

Steps:

2.6 Esterification of ALA in preparative scale
TEOF 12 ml (0.072 mol) and 1 g of Novozym 435 were added to ALA 20 g (0.072 mol). The mixture added of 10 μl of ethanol and incubated at 60 °C under shaking at 300 rpm. After 4 h the GC analysis evidenced the complete conversion of the substrate, and the reaction was stopped by filtering off the enzyme. The obtained oil, kept under vacuum (2 mbar) for 1 h at rt, furnished 22 g of ALA ethyl ester (in >99% yield), which nature was confirmed by comparison in GC analysis with an authentic sample.

References:

Morrone;D'Antona;Biondi;Lambusta;Nicolosi [Journal of Molecular Catalysis B: Enzymatic,2012,vol. 84,p. 173 - 176]

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