Micronomicin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Micronomicin, formerly called sagamicin, was found in the culture broth of Micromonospora sagamiensis var. nonreducans by Kyowa Hakko Kogyo Company and Abbott Laboratories in 1974. The compound is identical with one of the minor components contained in gentamicin, gentamicin C2b, but it is produced as a single component. Its amino group at the 6 -position is methylated and is not subject to the enzymatic acetylation caused by resistant bacteria, including Pseudomonas aeruginosa. Micronomicin is less toxic than gentamicin to the renal and aural systems.
Verwenden
Gentamicin C2b (micronomicin) is a trisaccharide pentaaminoglycoside antibiotic belonging to the gentamicin class. Gentamicin C2b was isolated from Micromonospora sagamiensis var. nonreductans by researchers at Kyowa Hakko Kogyo in 1974. Gentamicin C2b has broad activity against Gram positive and Gram negative bacteria. More recently, gentamicin C2b has been shown to induce neuromuscular blockage.
Antimicrobial activity
Antibacterial and pharmacokinetic properties are similar to
those of its precursor gentamicin C1a but it is more resistant to
AAC(6′). Dosage is similar to that for gentamicin, and should
be controlled by blood level determinations. It is available in
Japan.
Micronomicin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
