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REMIFENTANIL

REMIFENTANIL Struktur
132875-61-7
CAS-Nr.
132875-61-7
Englisch Name:
REMIFENTANIL
Synonyma:
Uluxa;Gi 87084x;REMIFENTANIL;Dea no. 9739;Remifentanyl;Unii-p10582jyyk;ZTVQQQVZCWLTDF-UHFFFAOYSA-N;132539-07-2 (Mono-hydrochloride);4-Methoxycarbonyl-4-(N-phenyl-N-propanoylamino)piperidine-1-propionic acid methyl ester;4-(Methoxycadx)nyl)-4-[(1-oxopropyl)phenylamino]-1-piperidinepropanoic acid methyl ester
CBNumber:
CB2470854
Summenformel:
C20H28N2O5
Molgewicht:
376.45
MOL-Datei:
132875-61-7.mol

REMIFENTANIL Eigenschaften

Siedepunkt:
487.8±45.0 °C(Predicted)
Dichte
1.171±0.06 g/cm3(Predicted)
pka
6.65±0.20(Predicted)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H370 Sch?digt die Organe. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P272 Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P307+P311 BEI Exposition: GIFTINFORMATIONSZENTRUM oder Arzt anrufen.
P321 Besondere Behandlung
P330 Mund ausspülen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

REMIFENTANIL Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Analgesic.

Definition

ChEBI: A piperidinecarboxylate ester that is methyl piperidine-4-carboxylate in which the hydrogen attached to the nitrogen is substituted by a 3-methoxy-3-oxopropyl group and the hydrogen at position 4 is substituted the nitrogen of N-propanoy aniline.

Weltgesundheitsorganisation (WHO)

Remifentanil is defined as an opioid narcotic with an addictionforming and addiction-sustaining liability similar to morphine.

Allgemeine Beschreibung

Remifentanil (Ultiva) was designed as a “soft drug.” Softdrugs are designed to undergo metabolism quickly and thushave ultrashort durations of action. In place of the ethylaromatic ring seen on the other piperidine opioids, remifentanilhas an ester group. This ester group is metabolizedby esterases in the blood and tissue to a weaklyactive metabolite (1:300–1:1,000 the potency of remifentanil). The n-octanol/water partition coefficient ofremifentanil is 17.9. The pKa of remifentanil is 7.07, thus itis predominately unionized at physiological pH. Both ofthese properties account for its rapid distribution across theblood-brain barrier (<1 minute). The ester hydrolysis leadsto a quick recovery (5–10 minutes) independent of durationof drug administration, renal, or liver function. The favorablepharmacodynamics of remifentanil have led to its usefor induction and maintenance of surgical anesthesia.

Pharmakologie

Remifentanil is a MOP agonist with a similar potency to fentanyl and approximately 20 times more than alfentanil. It has a rapid blood–brain equilibration time of just over 1min, with a short context-sensitive half-life of 3–5min, which is unaffected by duration of infusion. This makes it ideally suited for infusion during anaesthesia and in critical care. It may be titrated rapidly to achieve the desired effect. Remifentanil is available as a lyophilised white crystalline powder containing glycine; it should not be administered via the epidural or intrathecal routes. There may be increased opioid sensitivity in hepatic disease, resulting in a lower dosage requirement. Other situations requiring a reduction in dose include haemorrhage and shock and when administering in elderly patients. The high clearance and low VD imply that the offset of effect is caused by metabolism rather than redistribution. Hypothermia, such as may occur in cardiac surgery, may reduce clearance by up to 20%.
There is some evidence to suggest that acute opioid tolerance and hyperalgesia may occur, particularly after remifentanil infusions. If high doses are used without neuromuscular blockade, muscle rigidity may be a problem, though this is less likely if using a concentration of 100 μgml-1 or less and an infusion rate of 0.2–0.5μgkg-1 min-1. Bradycardia has also been reported.

REMIFENTANIL Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

132875-61-7()Verwandte Suche:


  • REMIFENTANIL
  • 4-(Methoxycadx)nyl)-4-[(1-oxopropyl)phenylamino]-1-piperidinepropanoic acid methyl ester
  • 4-[Propionyl(phenyl)amino]-1-[2-(methoxycarbonyl)ethyl]piperidine-4-carboxylic acid methyl ester
  • 4-Methoxycarbonyl-4-(N-phenyl-N-propanoylamino)piperidine-1-propionic acid methyl ester
  • 132539-07-2 (Mono-hydrochloride)
  • 1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester
  • Dea no. 9739
  • Gi 87084x
  • Unii-p10582jyyk
  • Remifentanyl
  • Uluxa
  • ZTVQQQVZCWLTDF-UHFFFAOYSA-N
  • 132875-61-7
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