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Sodium risedronate

Sodium risedronate Struktur
115436-72-1
CAS-Nr.
115436-72-1
Englisch Name:
Sodium risedronate
Synonyma:
Actonel;NE 58095;RISEDRONATE NA;risedronate,RID;NE 58095 Sodium;Sodium risedrote;RESIDROTE SODIUM;Risedronat sodium;RISEDRONATE SODIUM;RISEDREMATE SODIUM
CBNumber:
CB1414620
Summenformel:
C7H12NNaO7P2
Molgewicht:
307.11
MOL-Datei:
115436-72-1.mol

Sodium risedronate Eigenschaften

Schmelzpunkt:
252-262°C
storage temp. 
room temp
L?slichkeit
H2O: soluble5mg/mL, clear (warmed)
Aggregatzustand
powder
Farbe
white to beige
Wasserl?slichkeit
Soluble to 10 mM in water
BCS Class
3
Stabilit?t:
Hygroscopic
CAS Datenbank
115436-72-1(CAS DataBase Reference)

Sicherheit

R-S?tze: 62-64
S-S?tze: 20-22-36/37
WGK Germany  3
RTECS-Nr. SZ8567500
HS Code  29333990

Sodium risedronate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Risedronate sodium was launched as Actonel in the US for treatment of Paget's disease. Risedronic acid is readily obtained by condensation of 2-(3- pyridyl)acetic acid with phosphorous acid in presence of phosphorus oxychloride. Risedronate sodium is an orally active bisphosphonate of third generation, showing more potent bone antiresorptive properties than most of prior bisphosphonates like etidronate which has been used for the same indication since 1978. The biological mechanism by which Risedronate, and generally bisphosphonates, act is not quite clear presently ; recent advances have suggested that aminobisphosphonates interfere with the HMG-CoA pathway and inhibit protein prenylation, causing apoptosis of osteoclasts and macrophages. These apoptotic effects are correlated to the anti-resorptive properties of this class of compounds. In a 2 month clinical trial involving patients with Paget's desease, 30 mg risedronate daily achieved an appreciable reduction of serum alkaline phosphatase levels, an indicator of bone stabilization, in 77% of patients, compared with 11% on etidronate at 400 mg daily for 6 months. Risedronate is also in development for the treatment and prevention of various bone diseases, particularly post-menopausal and corticosteroid-induced osteoporosis.

Chemische Eigenschaften

Fine White to Off-White Crystalline Powder

Verwenden

Risedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor.

Hazard

Human systemic effects.

Biologische Aktivit?t

Orally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase. Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone reabsorption in vivo .

Sodium risedronate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sodium risedronate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 415)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Hebei Mojin Biotechnology Co.,Ltd
+86-15028179902
angelia@hbmojin.com China 1176 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Hi-Tech Chemistry Corp
0519-86626038
yuhh@hitechem.com CHINA 810 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58

115436-72-1()Verwandte Suche:


  • RISEDREMATE SODIUM
  • RISEDRONATE NA
  • RISEDRONATE SODIUM
  • RISEDRONIC ACID, SODIUM SALT
  • SODIUM RISEDRONATE
  • [1-hydroxy-2-(3-pyridinyl)ethylidene]-bis[phosphonic acid] monosodium salt
  • (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-phosphonicacimonosodiumsalt
  • risedronate,RID
  • 1-Hydroxy-2-(3-pyridinyl)ethylidenebisphosphonatemonosodiumhemipentahydrate
  • RISENDRONATE SODIUM
  • P,P'-[1-Hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonicacidsodiumsalt
  • Risedronate sodiuM hydrate
  • Risedronate Sodium (350 mg)
  • [1-Hydroxy-2-(3-pyridinyl)ethylidene]bis
  • NE 58095 Sodium
  • sodium hydrogen-1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethylphosphonate
  • P,P′-[1-Hydroxy-2-(3-pyridinyl)ethylidene]bis-phosphonic acid sodium
  • Sodium risedrote
  • monosodium(1-hydroxy-2-(3-pyridinyl)ethylidene)bisphosphonate
  • Risedronat sodium
  • RisedronateSodium&Int.
  • [1-Hydroxy-2-(3-pyridinyl)ethylidene]-bis[phosphonicacid]monosodiumsalthemi-pentahydrate
  • Actonel
  • NE 58095
  • Risedronic Acid Monosodium Salt
  • Risedronate Sodium Tablets
  • Risedronate (sodium salt)
  • Risedronic Acid Sodium
  • Risedronate Sodium Salt n -Hydrate
  • Risedronate sodium 2.5-hydrate CRS
  • Sodium risedronate,>98%
  • Phosphonic acid, P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-, sodium salt (1:1)
  • Sodium Risedronate CAS No. 115436-72-1powder USP35 Standards
  • Factory Supply Pharmaceutical API 99% Purity CAS 115436-72-1 Sodium Risedronate
  • Risedronate sodium (Risedronic Acid Sodium)
  • Risedronate sodiumQ: What is Risedronate sodium Q: What is the CAS Number of Risedronate sodium Q: What is the storage condition of Risedronate sodium Q: What are the applications of Risedronate sodium
  • 4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-44-THIOSEMICARBAZIDE
  • (1-Hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)bis(phosphonic acid) sodium salt
  • RESIDROTE SODIUM
  • 115436-72-1
  • 11546-72-1
  • C7H11NO7P2Na
  • C7H10NO7P2Na25H2O
  • C7H10NNaO7P2
  • C7H10NNaO7P225H2O
  • C7H11NNaO7P2
  • BELCOMYCINE
  • All Inhibitors
  • Osteoporosis
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Phosphorylating and Phosphitylating Agents
  • Heterocycles
  • Bone Resorption Inhibitor
  • Active Pharmaceutical Ingredients
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