Ponatinib
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- CAS-Nr.
- 943319-70-8
- Englisch Name:
- Ponatinib
- Synonyma:
- He he;CS-165;AP24534;ponatini;Ponatinib;Ponatinib Base;Ponatinib, >=98%;AP24534(Ponatinib);AP-24534; AP 24534;Ponatinib (AP24534)
- CBNumber:
- CB12518324
- Summenformel:
- C29H27F3N6O
- Molgewicht:
- 532.56
- MOL-Datei:
- 943319-70-8.mol
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Ponatinib Eigenschaften
- Schmelzpunkt:
- >175°C (dec.)
- Dichte
- 1.3
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
- Aggregatzustand
- Yellow powder.
- pka
- 12.99±0.70(Predicted)
- Farbe
- Yellow
- Stabilit?t:
- Stable for 2 years from date? of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- CAS Datenbank
- 943319-70-8
Ponatinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Pale Yellow Solid
Verwenden
Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors.
Definition
ChEBI: A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline.
Trademarks
Iclusig
TM
Ponatinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ponatinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 283)Lieferanten
- AP24534(Ponatinib)
- 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
- AP24534
- AP24534;PONATINIB;3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE
- Ponatinib
- 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide
- Ponatinib (AP24534)
- Ponatinib (with 4 ints.)
- 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
- 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide Ponatinib(AP24534) AP 24534
- AP24534 hybrochloride
- Ponatinib hybrochloride
- Ponatinib, >=98%
- PONATINIB (AP24534);AP 24534;AP-24534
- Ponatinib Base
- ponatini
- AP-24534; AP 24534
- CS-165
- Ponatinib, Free Base 99+%
- 3-(imidazo [ 1,2-b ]pyridazin-3-ylethyny 1)-4-methy 1- N-( 4-(( 4-methylpiperazin-l-yl)methyl)-3-(trifluo-romethyl)phenyl)benzamide
- Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-
- Ponatinib USP/EP/BP
- 943319-70-8 Ponatinib
- He he
- 943319-70-8
- 43319-70-8
- C29H27F3N6O
- Inhibitors
- Pharmaceuticals
- Tyrosine Kinase Inhibitors
- Potent multi-kinase and pan-BCR-ABL inhibitor.
- Heterocycles
- Intermediates & Fine Chemicals
- API
- 943319-70-8
