TMC-207
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- CAS-Nr.
- 843663-66-1
- Englisch Name:
- TMC-207
- Synonyma:
- Bedaquiline;1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol;Sirturo;6-Bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol;3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)-;3-Quinolineethanol, 6-bromo-alpha-(2-(dimethylamino)ethyl)-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-, (alphas,betar)-;141027;CS-751;TMC-207;R 207910
- CBNumber:
- CB12473722
- Summenformel:
- C32H31BrN2O2
- Molgewicht:
- 555.5
- MOL-Datei:
- 843663-66-1.mol
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TMC-207 Eigenschaften
- Schmelzpunkt:
- 104 °C
- Siedepunkt:
- 702.7±60.0 °C(Predicted)
- Dichte
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- Room temperature
- L?slichkeit
- Soluble in DMSO (10 mg/ml)
- Aggregatzustand
- solid
- pka
- 13.05±0.29(Predicted)
- Farbe
- White
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- CAS Datenbank
- 843663-66-1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H373 |
Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P314 |
Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen. |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P391 |
Verschüttete Mengen aufnehmen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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TMC-207 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In December 2012, the US FDA approved bedaquiline as part of combination
therapy for the treatment of multi-drug resistant tuberculosis (MDRTB).
Bedaquiline is the first drug approved for MDR-TB and is the first
approval from a new class of antituberculosis agents in the past 40 years.
Due to the high unmetmedical need for treating MDR-TB, the FDA granted
bedaquiline accelerated approval based on Phase II results, providing patients access to the drug while additional clinical studies are carried out. Bedaquiline (also known as TMC207 and R207910) is a diarylquinoline
that was discovered from a high-throughput, whole-cell screening
strategy with Mycobacterium smegmatis used as a surrogate for
M. tuberculosis. Bedaquiline is a single enantiomer of an initial screening
hit. Bedaquiline has potent and selective activity against mycobacteria, and
is active against both drug-sensitive and drug-resistant M. tuberculosis. The mechanism of action of bedaquiline is unique amongst anti-TB drugs and
involves inhibition of mycobacterial ATP synthase; it is not active against
human ATP synthase. Bedaquiline has in vivo activity in numerous preclinical models of TB infection, alone and in combination with other anti-TB agents, and has bactericidal activity in established TB infection models. Bedaquiline is synthesized in five steps from 3-phenylpropionic acid
and para-bromoaniline. Following amide formation, treatment with POCl
3
and DMF under Vilsmeier–Hack conditions gave a 2-chloroquinoline product.
Treatment with sodium methoxide, followed by condensation with
3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one, and separation of isomers
gave bedaquiline.
Verwenden
(αS,βR)-Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.
TMC-207 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
TMC-207 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 227)Lieferanten
843663-66-1()Verwandte Suche:
- TMC-207
- R 207910
- Bedaquiline(R 207910,TMC 207)
- Bedaquiline (TMC-207)
- (αS,βR)-Bedaquiline
- bedaquinline
- (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
- Bedaquiline D6
- (1R)-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2(S)-(1-naphthyl)-1-phenylbutan-2-ol
- (1R,2S)-1-(6-BroMo-2-Methoxyquinolin-3-yl)-4-(diMethylaMino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
- (αS,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol
- 141027
- TMC-207(Bedaquiline)
- CS-751
- BEDAQUILINE;TMC207;R207910;TMC 207;R 207910;TMC-207;R-207910
- TMC-207 USP/EP/BP
- BEDAQUILINE (TMC207, R207910)
- (1R)-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2(S)...
- Bedaquiline D6Q: What is
Bedaquiline D6 Q: What is the CAS Number of
Bedaquiline D6 Q: What is the storage condition of
Bedaquiline D6 Q: What are the applications of
Bedaquiline D6
- BedaquilineQ: What is
Bedaquiline Q: What is the CAS Number of
Bedaquiline Q: What is the storage condition of
Bedaquiline Q: What are the applications of
Bedaquiline
- Bedaquiline
- Sirturo
- 6-Bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
- 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol
- 3-Quinolineethanol, 6-bromo-alpha-(2-(dimethylamino)ethyl)-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-, (alphas,betar)-
- 3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)-
- (αS,βR)-Bedaquiline
- Bedaquline Fumarate
- (alphaS,betaR)-Bedaquiline
- (αS,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol
- Bedaguiline
- Bedaquinoline
- 843663-66-1
- C32H31BrN2O2
- C31H29BrN2O
- Inhibitors
- API
