11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat
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- CAS-Nr.
- 13609-67-1
- Bezeichnung:
- 11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat
- Englisch Name:
- Hydrocortisone-17-butyrate
- Synonyma:
- HYDROCORTISONE BUTYRATE;HYDROCORTISONE 17-BUTYRATE;Alfason;h.17b;locoid;Plancol;Laticort;hb(sub17);Nicotine Impurity 8;CORTISOL 17-BUTYRATE
- CBNumber:
- CB1230781
- Summenformel:
- C25H36O6
- Molgewicht:
- 432.56
- MOL-Datei:
- 13609-67-1.mol
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11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat Eigenschaften
- Schmelzpunkt:
- 210.0 to 214.0 °C
- Siedepunkt:
- 466.2°C (rough estimate)
- Dichte
- 1.0914 (rough estimate)
- Brechungsindex
- 1.4593 (estimate)
- storage temp.
- Refrigerator
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.98±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Merck
- 14,4787
- InChIKey
- BMCQMVFGOVHVNG-IZBZUILHNA-N
- SMILES
- O([C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO)C(=O)CCC |&1:1,4,6,16,18,20,23,r|
- CAS Datenbank
- 13609-67-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
2 |
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| RTECS-Nr. |
GM9002000 |
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| HS Code |
2937290000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Hydrocortisone 17-butyrate: a new non-fluorinated topical corticosteroid.
Hydrocortisone 17-butyrate could be used in psoriasis, eczema and other inflammatory dermatoses. It may be found in creams, lotions, ointments, and powders and in ear, nose and eye drops for rhinitis, otitis, and conjunctivitis. In double-blind paired comparisons with other topical corticosteroids, the efficacy of hydrocortisone 17-butyrate 0.1% has generally been indistinguishable from that of triamcinolone acetonide 0.1%, fluocinolone acetonide 0.025% or betamethasone 17-valerate 0.1% in patients with eczema or psoriasis. When applied to the face of patients with atrophy superimposed on rosacea and perioral dermatitis resulting from prolonged use of fluorinated topical corticosteroids, hydrocortisone 17-butyrate 0.1% did not prevent the beneficial effect of systemic tetracycline nor the disappearance of telangiectasis and tended to be more effective than hydrocortisone 1%[1].
Verwenden
Hydrocortisone-17-butyrate is a topical corticosteroid with anti-inflammatory properties; marker for topical corticosteroid allergy.
Definition
ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group.
Kontakt-Allergie
Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti-
sone. It represents the D2 group of corticosteroids, non
C 16 methylated with a C 17 ester: hydrocortisone
17-butyrate, hydrocortisone 17-valerate, hydrocortisone
aceponate (17-propionate and 21-acetate), methylpred-
nisolone aceponate, and prednicarbate. It is sometimes
hydrolyzed in vivo into hydrocortisone, giving allergic
reactions to group-A-sensitized people.
11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 256)Lieferanten
13609-67-1(11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat)Verwandte Suche:
Flumetason
Corticosteron
Progesteron
Hydrocortison
3,20-Dioxopregn-4-en-17-β-ylacetat
11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat
Cortodoxon
Cortison
Buttersure
11-β-Hydroxypregn-4-en-3,20-dion
Desoxycorton
11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-butyrat-21-propionat
11β,17,21-Trihydroxypregn-4-en-3,20-dion-17-valerat
11-β,17-α-Dihydroxypregn-4-en-3,20-dion
- CORTISOL 17-BUTYRATE
- 11b,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate
- 11BETA,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 17-BUTYRATE
- 11-beta,17-alpha,21-trihydroxy-4-pregnene-3,20-dione17-alpha-butyrate
- h.17b
- hb(sub17)
- hydrocortisone17-alpha-butyrate
- locoid
- Hydrocortisone Butyrate USP
- 4-Pregnene-11β,21-dihydroxy-17α-butyryloxy-3,20-dione
- Butyric acid, 17-ester with cortisol (8CI)
- Cortisol, 17-butyrate (6CI, 8CI)
- Laticort
- Plancol
- Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11β)-
- 21-dihydroxy-17-(1-oxobutoxy)-20-dion (11-beta)-pregn-4-ene-11
- 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate, Cortisol 17-butyrate
- 17α-(Butyryloxy)corticosterone
- Hydrocortisone Butyrate (200 mg)
- Hydrocortisone-17-bu
- 2-((8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-diMethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl butyrate
- Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11.beta.)-
- 11β,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate
- Hydrocortisone butyrate 13609-67-1
- Hydrocortisone17-Butyrate>
- Hydrocortisone-17-butyrate USP/EP/BP
- Hydrocortisone Butyrater
- Hydrocortisone Butyrate (1317302)
- HYDROCORTISONE 17-BUTYRATE
- HYDROCORTISONE BUTYRATE
- Alfason
- 4-PREGNEN-11β, 17, 21-TRIOL-3, 20-DIONE-17-BUTYRATE
- (8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl butyrate
- C14224030 HydrocortisonE17-Butyrate
- Nicotine Impurity 8
- 13609-67-1
- 609-67-1
- 3609-67-1
- C25H36O6
- BioChemical
- Cell Biology
- Steroid Hormones
- Hormones
- Cytokines, Growth Factors and Hormones
- Cell Signaling and Neuroscience
- NOVANTRONE
- Steroid and Hormone
- Steroids
- 13609-67-1
