Primidon
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Primidon Eigenschaften
- Schmelzpunkt:
- 281-282°C
- Siedepunkt:
- 358.94°C (rough estimate)
- Dichte
- 1.1402 (rough estimate)
- Brechungsindex
- 1.6660 (estimate)
- Flammpunkt:
- 9℃
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Very slightly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in alkaline solutions.
- Aggregatzustand
- Solid
- pka
- 12.26±0.40(Predicted)
- Farbe
- White to Off-White
- Wasserl?slichkeit
- <0.1 g/100 mL at 19 ºC
- Merck
- 14,7746
- BCS Class
- 2
- InChIKey
- DQMZLTXERSFNPB-UHFFFAOYSA-N
- CAS Datenbank
- 125-33-7(CAS DataBase Reference)
- IARC
- 2B (Vol. 108) 2016
- NIST chemische Informationen
- Primidone(125-33-7)
- EPA chemische Informationen
- Primidone (125-33-7)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn,T,F | ||
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R-S?tze: | 22-40-39/23/24/25-23/24/25-11 | ||
S-S?tze: | 22-36-45-36/37-16-7 | ||
RIDADR | 3249 | ||
WGK Germany | 3 | ||
RTECS-Nr. | UV9100000 | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
HS Code | 29335990 | ||
Giftige Stoffe Daten | 125-33-7(Hazardous Substances Data) | ||
Toxizit?t | child,TDLo,oral,625mg/kg (625mg/kg),BEHAVIORAL: SLEEPBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: GENERAL ANESTHETIC,British Medical Journal. Vol. 1, Pg. 90, 1957. |
Bildanzeige (GHS) |
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Primidon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.R40:Verdacht auf krebserzeugende Wirkung.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
Primidone is chemically and structurally similar to phenobarbital with the exception that the carbonyl group on C2 is replaced by a methylene group. This modification leads to the production of a drug with strong anticonvulsant properties without expressed soporific effects.Chemische Eigenschaften
Crystalline SolidVerwenden
Primidone is mainly used for major attacks.Definition
ChEBI: A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.Allgemeine Beschreibung
Odorless white crystalline powder. Slightly bitter taste. No acidic properties.Air & Water Reaktionen
Insoluble in water.Reaktivit?t anzeigen
Primidone is an amide. May react with azo and diazo compounds to generate toxic gases. May react with strong reducing agents to form flammable gases. A very weak base. The Combustion generates toxic mixed oxides of nitrogen (NOx).Brandgefahr
Flash point data for Primidone are not available; however, Primidone is probably combustible.Biologische Aktivit?t
Anticonvulsant.Clinical Use
Primidone is the 2-deoxy derivative of phenobarbital and is approved by the U.S. FDA for initial or adjunctive treatment of simple partial, complex partial, and tonic-clonic seizures. It is less effective against these types of seizures than is phenytoin or CBZ, and it shares the antiseizure and sedative actions of phenobarbital. Although not approved for the purpose, it often is used to treat benign familial tremor (essential tremor).Nebenwirkungen
As with phenobarbital, serious toxicity for primidone is rare, although it may cause disabling sedation, irritability, and decreased mental functioning in a number of persons. Ataxia, dysphoria, idiosyncratic rash, leukopenia, agranulocytosis, lymphadenopathy, hepatitis, and a systemic lupus erythematosus–like syndrome have been reported adverse effects for primidone. Deficiencies of folic acid and of vitamins D and K are possible with long-term therapy of primidone, as is a folateresponsive megaloblastic anemia. Measurement of the complete blood cell count should be performed at 6-month intervals.Sicherheitsprofil
Poison by ingestion and intraperitoneal routes. Human teratogenic effects include developmental abnormalities of the craniofacial area, skin and skin appendages, and cardlovascular system. Human reproductive effects: effects on newborn, including unusual growth statistics, drug dependence, physical and other neonatal changes. Experimental teratogenic and reproductive effects. Human mutation data reported. An addictive drug. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES.Primidon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Primidon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 295)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21628 | 55 |
Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 |
sales@amoychem.com | China | 6383 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49732 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32159 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
sales@afinechem.com | China | 15395 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 8772 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24727 | 58 |
TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38630 | 58 |
125-33-7(Primidon)Verwandte Suche:
Hydroxyethyl Cellulose
2-Ethyl-3-hydroxy-4H-pyran-4-on
Ethyl cellulose
Phenylsalicylat
Hydroxyethyl starch
Sulfadiazin
Ethylacetat
Phenylvalerat
Triphenylphosphin
Diphenylether
(4-Amino-N-pyrimidin-2-ylbenzolsulfonamidato-NN,O1)silber
Ethyl-4-hydroxybenzoat
Ethanol
PHENYL RESIN
Phenylaceton
Phenylessigsure
5-Ethyldihydro-5-(p-tolyl)-1H,5H-pyrimidin-4,6-dion
5-Ethyl-5-phenyl-barbiturs?ure
- Resimatil
- Roe 101
- roe101
- Sertan
- 5-ETHYLDIHYDRO-5-PHENYL-4,6(1H,5H)-PYRIMIDINEDIONE
- 5-phenyl-5-ethyl-hexahydropyrimidine-4,6-dione
- PRIMIDONE
- 5-ethyl-5-phenylperhydropyrimidine-4,6-dione
- PRIMIDONE,USP
- 4,6-PYRIMIDINEDIONE,5-ETHYLDIHYDRO-5-PHENYL
- 5-ETHYLDIHYDRO-5-PHENYL-4,6-PYRIMIDINEDIONE
- 5-Ethyl-5-phenyl-1,3-diazinane-4,6-dione
- Misoline
- Mizoline
- 5-Ethyldiiodro-5-phenyl-4,6(1H,5H)-pyrimidinedione
- 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-quinone
- Primidone (200 mg)H0D3991.000mg/mg(dr)
- PriMidone API
- 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione 2-Deoxyphenobarbital
- PriMidone (Mysoline)
- 5-ethyl-5-phenyldihydropyriMidine-4,6(1H,5H)-dione
- Primidone solution
- 2-deoxyphenobarbital
- 2-DESOXYPHENOBARBITAL
- 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-
- 5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion
- 5-Ethyl-5-phenyldihydro-4,6(1H,5H)-pyrimidinedione
- 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione
- 5-ethylhexahydro-4,6-dioxo-5-phenylphrimidine
- 5-Ethylhexahydro-4,6-dioxo-5-phenylpyrimidine
- 5-Ethylhexahydro-5-phenylpyrimidine-4,6-dione
- 5h)-pyrimidinedione,5-ethyldihydro-5-phenyl-6(1h
- 5-Phenyl-5-aethylhexahydropyrimidindion-(4,6)
- Cyral
- Desoxyphenobarbitone
- Hexadiona
- hexamidine(theantispasmodic)
- Lepimidin
- Lepsiral
- Liskantin
- Majsolin
- Medi-Pets
- Midone
- Milepsin
- Misodine
- Misolyne
- Mizodin
- Mizolin
- Mylepsin
- Mylepsinum
- Mysedon
- Mysoline
- NCI-C56360
- Neurosyn
- Prilepsin
- Primacione
- Primaclone
- Primacone