4-Pyridincarbons?ure-2-(1-methyl-ethyl)hydrazid
|
|
|
- CAS-Nr.
- 54-92-2
- Bezeichnung:
- 4-Pyridincarbons?ure-2-(1-methyl-ethyl)hydrazid
- Englisch Name:
- iproniazid
- Synonyma:
- IPRAZID;Marsilid;iproniazid;Iproniazid>n’-isopropylisonicotinohydrazide;1-Isonicotinoyl-2-isopropylhydrazine;N'-Isopropylpyridine-4-Carbohydrazide;Isonicotinic Acid 2-Isopropylhydrazide;N'-propan-2-ylpyridine-4-carbohydrazide;Isonicotinic acid N'-isopropyl-hydrazide
- CBNumber:
- CB0928533
- Summenformel:
- C9H13N3O
- Molgewicht:
- 179.22
- MOL-Datei:
- 54-92-2.mol
|
4-Pyridincarbons?ure-2-(1-methyl-ethyl)hydrazid Eigenschaften
- Schmelzpunkt:
- 112.5-113.5°
- Siedepunkt:
- 311.75°C (rough estimate)
- Dichte
- 1.1305 (rough estimate)
- Brechungsindex
- 1.5100 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 11.28±0.23(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Pale Beige
- CAS Datenbank
- 54-92-2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| HS Code |
2933399990 |
|
|
| Toxizit?t |
An isopropyl derivative of isoniazid that was
found to have mood-elevating effects in tuberculosis patients.
It was later found to be a monoamine oxidase (MAO) inhibitor
and, although not currently approved for clinical use as an
antidepressant due to its propensity to cause liver damage it
led to the development of other MAO inhibitors currently in
use. In addition to hepatotoxic effects, iproniazid is a hypotensive
agent and can cause potentially hazardous reactions with
other drugs and amine-rich foods. |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
4-Pyridincarbons?ure-2-(1-methyl-ethyl)hydrazid Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.
Weltgesundheitsorganisation (WHO)
Iproniazid, a monoamine oxidase inhibitor (MAOI), was
introduced in 1952 for the treatment of depressive illness. Subsequently concern
regarding potentially serious interactions between MAOIs and foods containing
tyramine inspired much restrictive regulatory action. However, MAOIs still retain a
place in the treatment of serious depressive illness although there is no
international consensus on which compounds should be preferred. Thus iproniazid
remains available in several countries.
l?uterung methode
Crystallise it from *benzene or *benzene /pet ether and dry it in a vacuum. It is soluble in H2O and EtOH. [Fox & Gibas J Org Chem 18 994 1953.] The dihydrochloride has m 227-228o (from EtOH). [Beilstein 22 III/IV 551.] It is an antidepressant.
4-Pyridincarbons?ure-2-(1-methyl-ethyl)hydrazid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-Pyridincarbons?ure-2-(1-methyl-ethyl)hydrazid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 88)Lieferanten
54-92-2(4-Pyridincarbons?ure-2-(1-methyl-ethyl)hydrazid)Verwandte Suche:
- iproniazid
- IPRAZID
- N'-propan-2-ylpyridine-4-carbohydrazide
- N'-Isopropylpyridine-4-Carbohydrazide
- 1-Isonicotinoyl-2-isopropylhydrazine
- Isonicotinic Acid 2-Isopropylhydrazide
- Iproniazid>
- Marsilid
- 4-Pyridinecarboxylicacid, 2-(1-methylethyl)hydrazide
- Isonicotinic acid N'-isopropyl-hydrazide
- n’-isopropylisonicotinohydrazide
- 54-92-2
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Neurochemicals
- Pharmaceuticals
