Mometasone furoate
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- CAS-Nr.
- 83919-23-7
- Englisch Name:
- Mometasone furoate
- Synonyma:
- NASONEX;Mometason Furoate;MOMETASONE 17-FUROATE;(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-pregna-1,4-diene-3,20-dione;Ecural;ElocoM;EloMet;Monovo;AsManex;SCH-32088
- CBNumber:
- CB0725569
- Summenformel:
- C27H30Cl2O6
- Molgewicht:
- 521.43
- MOL-Datei:
- 83919-23-7.mol
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Mometasone furoate Eigenschaften
- Schmelzpunkt:
- 218-220°C
- alpha
- D26 +58.3° (dioxane)
- Siedepunkt:
- 655.5±55.0 °C(Predicted)
- Dichte
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥20mg/mL
- pka
- 13.02±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Optische Aktivit?t
- [α]/D +50 to +60°, c = 0.5 in methanol
- InChIKey
- WOFMFGQZHJDGCX-ZULDAHANSA-N
- SMILES
- C[C@]12C[C@H](OC(=O)C3=CC=CO3)C3([C@](CCC4[C@]3(C)C=CC(=O)C=4)([H])[C@]1([H])C[C@@H](C)[C@]2(OC(=O)C1OC=CC=1)C(=O)CCl)Cl |&1:1,3,13,17,25,28,30,r|
- CAS Datenbank
- 83919-23-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
29372290 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
| P403+P233 |
An einem gut belüfteten Ort aufbewahren. Beh?lter dicht verschlossen halten. |
| P405 |
Unter Verschluss aufbewahren. |
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Mometasone furoate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Mometasone furoate is a topical steroidal antiinflammatory useful in the treatment of
corticosteroid-responsive dermatoses. As a steroidal antiinflammatory of grade II
potency, mometasone furoate is characterized by a once-daily dose regimen and a
relatively wide safety margin.
Chemische Eigenschaften
White-to-Off-White Solid
Verwenden
Mometasone furoate is a deuterated topical corticosteroid used as an anti-inflammatory. Mometasone furoate has been used to study its effect on Leishmania major amastigotes. It could as labeled Mometasone, intended for use as an internal standard for the quantification of Mometasone by GC- or LC-mass spectrometry. Formulations containing mometasone furoate have been used in the treatment of allergic rhinitis, atopic dermatitis, and asthma. Intranasal administration of mometasone furoate (1 μg/nostril) reduces the frequency of sneezing and nasal rubbing in a rat model of histamine-induced allergic rhinitis. Topical application of mometasone furoate reduces croton oil-induced ear edema in mice (ED50 = 0.31 μg/ml).
Biologische Funktion
Mometasone furoate has strong local
anti-inflammatory activity equivalent to that of fluticasone propionate. It has a quick onset of action relative to
the other inhaled/intranasal steroids with the least systemic availability and, consequently, the fewest systemic
side effects.
Allgemeine Beschreibung
Mometasone furoate (Asmanex,Nasonex) undergoes extensive metabolism to multiplemetabolites. No major metabolites are detectable in humanplasma after oral administration, but the 6β-hydroxy metaboliteis detectable by use of human liver microsomes. Thismetabolite is formed via the CYP3A4 pathway.
Mechanism of action
Mometasone furoate is the most recent glucocorticoid to be developed and commercialized. It has
a number of unique functional groups that confer enhanced glucocorticoid activity as well as
pharmacokinetic advantages. The combination of the C-21 chloro and the furoic acid ester at
C-17 results in the highest glucocorticoid receptor affinity of any topical corticosteroid. The 16α-
methyl decreases the mineralocorticoid effects, and the 9α-chloro group increases both
glucocorticoid and mineralocorticoid activities. Inhaled mometasone furoate acts locally as an
anti-inflammatory treatment for asthma and has the least systemic bioavailability of all the
inhaled glucocorticoids (<1%).
Clinical Use
Mometasone furoate was originally marketed as a topically applied corticosteroid, but because of its low
systemic bioavailability, it was found to be more useful in the treatment of allergic disorders and lung diseases
(107).
Stoffwechsel
It is extensively metabolized, with 6β-hydroxymometasone and
21-hydroxymometasone being found among the metabolites. Inhaled mometasone furoate in
mainly excreted in the feces (~74%) as metabolites and only minimally excreted in the urine
(~8%). It has a relatively long half-life in the lung and is administered once daily, usually in the
evening.
Mometasone furoate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
2-Furoylchlorid
Lithiumchlorid
N,N-Dimethylpyridin-4-amin
11β,16α,17,21-Tetrahydroxypregna-1,4-dien-3,20-dion
Methansulfonylchlorid
4,5-Dichlor-3,6-dioxocyclohexa-1,4-dien-1,2-dicarbonitril
Downstream Produkte
Mometasone furoate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 620)Lieferanten
83919-23-7()Verwandte Suche:
- SCH-32088
- MOMETASONE FUROATE
- (11-beta,16-alpha)-xy-16-methyl
- pregna-1,4-diene-3,20-dione,9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydro
- 9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate
- (11BETA,16ALPHA)-9,21-DICHLORO-17-[(2-FURANYLCARBONYL)OXY]-11-HYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
- MOMETASONE FUAROATE
- MometasoneFuorateBp/Ep/Usp
- Pregna-1,4-Diene-3,20-Dione,9,21-Dichloro-17-[(2-Furanylcarbonyl)Oxy]-11-Hydroxy-16-Methyl-,(11Beta,16Alpha)-
- (+)-9,21-Dichloro-11',17'-dihydroxy-16-alpha-methyl-1,4-pregnadiene-3,20-dione-17-(2-furoate)
- Sch-32088, Elocon, Nasonex
- Mometasone 17-(2-furoate)
- Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-, (11b,16a)- (9CI)
- MOMETOSONE FUROATE MONOHYDRATE
- srh-32088
- 9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
- 9,21-Dichloro-17-[[(furan-2-yl)carbonyl]oxy]-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
- 9α,21-Dichloro-11β-hydroxy-16α-methyl-17α-[(2-furanyl)carbonyloxy]pregna-1,4-diene-3,20-dione
- 9α,21-Dichloro-17α-[[(furan-2-yl)carbonyl]oxy]-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
- 11β,16α)-9,21-Dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl2-furoate
- Mometasone Furoate (200 mg)
- Mometasone Furoate (200 mg)H0E0090.998mg/mg(dr)
- Twisthaler
- 9，21-Dichloro-11β，17-hydrox-16α-methylpregm-1，4-diene-3，20-dione 17-(2-furoate)
- AsManex
- AsManex Twisthaler
- Ecural
- ElocoM
- EloMet
- Monovo
- Mometasone furoate Solution, 100ppm
- Mometasone Furoate （DMF）
- 2-furancarboxylic acid [(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloro-1-oxoethyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
- Mometasone furoate CRS
- MometasoneFuroate>
- Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-, (11β,16α)-
- (8S,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-11,17-diyl bis(furan-2-carboxylate)
- Mometasone furoate USP/EP/BP
- Mometasone Furoate-13C,d6
- Mometasone furoateQ: What is
Mometasone furoate Q: What is the CAS Number of
Mometasone furoate Q: What are the applications of
Mometasone furoate
- Mometasone furoate D3Q: What is
Mometasone furoate D3 Q: What is the CAS Number of
Mometasone furoate D3 Q: What is the storage condition of
Mometasone furoate D3 Q: What are the applications of
Mometasone furoate D3
- Mometasone Furoate (1445470)
- Flecainida
- Flecainidum
- MOMETASONE 17-FUROATE
- NASONEX
- Mometaso Furoate
- (11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-pregna-1,4-diene-3,20-dione
- Mometason Furoate
- metasone furoate
- Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-, (11β,16α)-
- Mometasone Furoate Anhydrous
- Mometasone furoate/Mometasone furoate
- (8S,9R,10S,11S,13S,14S,16R,17R)-9-Chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
- (8s,9r,10s,11s,13s,14s,16r,17r)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Furan-2-carboxylate
- 83919-23-7
- C27H30Cl2O6
- Hormone Drugs
