JASPLAKINOLIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC₅₀ = 35 nM) by binding F-actin (KD = 15 nM). This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo. This compound is used to investigate the role of actin in diverse cellular roles, such as motility, transport, and development.

Verwenden

Jasplakinolide is a potent inhibitor of prostrate and breast carcinoma cell proliferation. Also acts as an actin stabilizing agent, affecting chromosome movement in studies.

Definition

ChEBI: A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity.

JASPLAKINOLIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

JASPLAKINOLIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Wuhan Fortuna Chemical Co.,Ltd	+8618007136271	hk@fortunachem.com	China	6000	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94657	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32321	50
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 1316706386	anhua.mao@aladdin-e.com	China	25003	65
Shanghai Tauto Biotech Co., Ltd.	021-51320588	tauto@tautobiotech.com	China	3989	66
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8065	58

102396-24-7()Verwandte Suche:

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• JASPLAKINOLIDE
• JASPLAKINOLIDE, JASPIS JOHNSTONI
• (3S,6R,9R,13S,15R,16E,19S)-3,5,13,15,17,19-Hexamethyl-6-[(2-bromo-1H-indole-3-yl)methyl]-9-(4-hydroxyphenyl)-12-oxa-2,5,8-triazacyclononadeca-16-ene-1,4,7,11-tetraone
• [3S,6R,9R,13S,15R,19S,16E,(+)]-6-[(2-Bromo-1H-indol-3-yl)methyl]-9-(4-hydroxyphenyl)-3,5,13,15,17,19-hexamethyl-2,5,8-triaza-12-oxacyclononadecan-16-ene-1,4,7,11-tetrone
• NSC 613009
• Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem
• Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
• GQWYWHOHRVVHAP-DHKPLNAMSA-N
• Jasplakinolide, Actin polymerization and stabilization inducer
• 102396-24-7
• Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals