IMD-0354
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- CAS-Nr.
- 978-62-1
- Englisch Name:
- IMD-0354
- Synonyma:
- IMD 0354;IMD-0354;IMD-0354 USP/EP/BP;IKK-2 INHIBITOR V; IMD 0354;IMD0354;;IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem;IMD-0354, 99%, a synthetic selective NF-kB inhibitor;Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-;IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354;N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354
- CBNumber:
- CB0503637
- Summenformel:
- C15H8ClF6NO2
- Molgewicht:
- 383.67
- MOL-Datei:
- 978-62-1.mol
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IMD-0354 Eigenschaften
- Siedepunkt:
- 323.1±42.0 °C(Predicted)
- Dichte
- 1.561
- storage temp.
- -20°C
- L?slichkeit
- DMSO (5 mg/ml) or Ethanol (1 mg/ml).
- Aggregatzustand
- White solid
- pka
- 7.61±0.43(Predicted)
- Farbe
- White to off-white
- Sensitive
- Light Sensitive
- CAS Datenbank
- 978-62-1
IMD-0354 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.
Biologische Aktivit?t
Inhibitor of I κ B kinase-2 (IKK-2, IKK- β ) that blocks NF- κ B nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G 0 /G 1 cell cycle arrest and apoptosis in HMC-1? and breast cancer cells.
Biochem/physiol Actions
IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. [4]
IMD-0354 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
IMD-0354 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 99)Lieferanten
978-62-1()Verwandte Suche:
- Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-
- N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354
- IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem
- IKK-2 INHIBITOR V; IMD 0354;IMD0354;
- IMD-0354, 99%, a synthetic selective NF-kB inhibitor
- IMD 0354;IMD-0354
- IMD-0354 USP/EP/BP
- IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354
- 978-62-1
- C15H8ClF6NO2
- NF-kB
- Inhibitors
- Intracellular Signaling
