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Cetyl-pyridinium-chlorid

Cetylpyridinium chloride Struktur
123-03-5
CAS-Nr.
123-03-5
Bezeichnung:
Cetyl-pyridinium-chlorid
Englisch Name:
Cetylpyridinium chloride
Synonyma:
1-palmitylpyridiniumchloride;1-HEXADECYLPYRIDINIUM CHLORIDE;ceprim;ceepryn;cepacol;aktivex;biosept;merocet;cetamium;dobendan
CBNumber:
CB0492441
Summenformel:
C21H38ClN
Molgewicht:
339.99
MOL-Datei:
123-03-5.mol

Cetyl-pyridinium-chlorid Eigenschaften

Schmelzpunkt:
77°C
Siedepunkt:
496.25°C (rough estimate)
Dichte
0.9362 (rough estimate)
Dampfdruck
0Pa at 25℃
Brechungsindex
1.6000 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
Freely soluble in water; very soluble in chloroform; very slightly soluble in ether; insoluble in acetone, acetic acid, and ethanol.
Aggregatzustand
White Crystalline Powder
Farbe
White to off-white
Geruch (Odor)
at 100.00?%. pyridine
Wasserl?slichkeit
111g/L at 20℃
Stabilit?t:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
LogP
1.71 at 20℃
CAS Datenbank
123-03-5(CAS DataBase Reference)
EPA chemische Informationen
Cetylpyridinium chloride (123-03-5)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
RIDADR  2811
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933399990
Giftige Stoffe Daten 123-03-5(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H330 Lebensgefahr bei Einatmen. Akute Toxizit?t inhalativ Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Cetyl-pyridinium-chlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic activities. It is active against S. mutans, S. sanguis, E. coli, Oxford Staphylococcus, and C. albicans in media (MICs = 1.25-62.5 μg/ml) and against Oxford Staphylococcus in pooled human saliva (MICs = 7.8-15.6 μg/ml). Cetylpyridinium slows plaque formation for at least 21 days compared to a deionized water control in a rat incisor plaque model when applied topically at concentrations ranging from 0.025 to 2%. Formulations containing cetylpyridinium have been used as antiseptic agents in the treatment of gingivitis and as antimicrobial agents in raw food processing.

Chemische Eigenschaften

Cetylpyridinium chloride (CPC) is a white powder or crystals with a characteristic odor. It is slightly soapy to the touch.
Cetylpyridinium chloride
Cetylpyridinium chloride is a quaternary ammonium compound and is the active chemical in some human mouthwashes on the market. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat. The antimicrobial activity is due to an interaction of basic cetylpyridinium ions with acidic molecules on bacteria, which subsequently inhibits bacterial metabolism by forming weak ionic compounds that interfere with bacterial respiration.

Verwenden

Antibacterial in cough lozenges and syrups; emulsifier.

Definition

ChEBI: A pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat.

Vorbereitung Methode

Cetylpyridinium chloride is prepared from cetyl chloride by treatment with pyridine.

Pharmazeutische Anwendungen

Cetylpyridinium chloride is a quaternary ammonium cationic surfactant, used in pharmaceutical and cosmetic formulations as an antimicrobial preservative. It is used therapeutically as an antiseptic agent; used alone or in combination with other drugs for oral and throat care; used in nonparenteral formulations licensed in the UK; and used in oral and inhalation preparations at concentrations of 0.02–1.5 mg.
Mouthwashes containing cetylpyridinium chloride have been shown to inhibit plaque formation,(1–3) although efficacy is variable owing to limited published data.

Clinical Use

1-Hexadecylpyridinium chloride is a white powder that isvery soluble in water and alcohol. In this compound, thequaternary nitrogen atom is a member of an aromatic pyridinering.
The cetyl derivative is the most active of a series ofalkylpyridinium compounds. It is used as a general antisepticin concentrations of 1:100 to 1:1,000 for intact skin,1:1,000 for minor lacerations, and 1:2,000 to 1:10,000 forthe irrigation of mucous membranes. Cetylpyridinium chlorideis also available in the form of throat lozenges and amouthwash at a 1:20,000 dilution.

Sicherheitsprofil

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by skin contact. A skin and eye irritant. When E heated to decomposiuon it emits very toxic fumes of NOx and Cl-.

Sicherheit(Safety)

Cetylpyridinium chloride is used widely in mouthwashes as a bactericidal antiseptic. It is generally regarded as a relatively nontoxic material when used at a concentration of 0.05% w/v, although minor side effects such as mild burning sensations on the tongue have been reported.
At higher concentrations, cetylpyridinium chloride may damage the mucous membranes in the mouth. It is harmful when ingested or inhaled. It can cause eye irritation, and is irritant to the respiratory system and the skin.
LD50 (rat, IP): 0.006 g/kg
LD50 (rat, IV): 0.03 g/kg
LD50 (rat, oral): 0.2 g/kg
LD50 (rat, SC): 0.25 g/kg
LD50 (mouse, IP): 0.01 g/kg
LD50 (mouse, oral): 0.108 g/kg
LD50 (rabbit, oral): 0.4 g/kg
LD50 (rabbit, IV): 0.036 g/kg

Lager

Cetylpyridinium chloride is stable under normal conditions. It should be stored in well-closed containers.

Inkompatibilit?ten

Incompatible with strong oxidizing agents and bases. It is also incompatible with methylcellulose.
Magnesium stearate suspensions in cetylpyridinium chloride have been shown to significantly reduce its antimicrobial activity. This is due to the absorption of cetylpyridinium chloride on magnesium stearate. The cetylpyridinium chloride ion also interacts with gelatin, resulting in reduced bioavailability.

Regulatory Status

Included in nonparenteral formulations licensed in the UK. Included in the FDA Inactive Ingredients Database, for use in inhalation and oral preparations. Reported in the EPA TSCA Inventory. It is not approved for use in Japan. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Cetyl-pyridinium-chlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cetyl-pyridinium-chlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 412)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 3010 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55

123-03-5(Cetyl-pyridinium-chlorid)Verwandte Suche:


  • acetoquatcpc
  • aktivex
  • ammonyxcpc
  • biosept
  • ceeprinchloride
  • ceepryn
  • ceeprynchloride
  • cepacol
  • cepacolchloride
  • ceprim
  • cetamium
  • dobendan
  • fixanolc
  • intexsancpc
  • medilave
  • merocet
  • n-cetylpyridiniumchloride
  • pristacin
  • Pyridinium,1-hexadecyl-,chloride
  • pyrisept
  • HEXADECYL PYRIDINIUM CHLORIDE
  • CETYLPYRIDINIUM CHLORIDE
  • CETYL PYRIDINIUM CHLORINE
  • 1-cetylpyridiniumchloride
  • 1-hexadecyl-pyridiniuchloride
  • quaternariocpc
  • N-HEXADECYLPYRIDINIUM CHLORIDE
  • Cetypyridinium
  • CETYLPYRIDINIUMCHLORIDEANHYDROUS
  • tserigel
  • CETYLPYRIDINECHLORIDE
  • Cetylpyridiniumchlorid
  • C16-alkylpyridinium chloride
  • Cetylpyridinium chloride, 99% (Assay)
  • Cetyl Pyridinium Chloride USP
  • Cetylpyridine chloride monohydrate
  • 1-hexadecylpyridin-1-iuM chloride
  • Pyridinium, 1-hexadecyl-, chloride (1:1)
  • lpyridinium chloride
  • [C16Py]Cl
  • 1-Hexadecanepyridinium Chloride
  • Cetylpyridinium chloride USP/EP/BP
  • 1-naphthol-5-sulfoni
  • Cetylpyridinium Chloride (CPC)
  • Cetylpyridinium chlorideQ: What is Cetylpyridinium chloride Q: What is the CAS Number of Cetylpyridinium chloride Q: What is the storage condition of Cetylpyridinium chloride Q: What are the applications of Cetylpyridinium chloride
  • Cetylpyridinium chloride cas
  • 1-palmitylpyridiniumchloride
  • 1-HEXADECYLPYRIDINIUM CHLORIDE
  • Cium chloride
  • 123-03-5
  • 123-03-05
  • 23-03-5
  • C21H38NCl
  • C21H38Cl2N
  • Surfactants
  • Heterocyclic Quarternary Ammonium Salts (Surfactants)
  • Cationic Surfactants
  • Pyridinium Compounds
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