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5-α-Pregnan-3,20-dion

5α-Pregnane-3,20-dione Struktur
566-65-4
CAS-Nr.
566-65-4
Bezeichnung:
5-α-Pregnan-3,20-dion
Englisch Name:
5α-Pregnane-3,20-dione
Synonyma:
Pregnane-3,20-dione;5α-dihydroprogesterone;5α-Dihydroprogesterone;5α-pregnane-3,20-dione;ALLOPREGNANDIONE;Allopregnanedione;Pregnane-3,20-dlone;Estrone Impurity 23;5A-PREGNAN-3,20-DIONE;5A-DIHYDROPROGESTERONE
CBNumber:
CB0377209
Summenformel:
C21H32O2
Molgewicht:
316.48
MOL-Datei:
566-65-4.mol

5-α-Pregnan-3,20-dion Eigenschaften

Schmelzpunkt:
200 °C
Siedepunkt:
429.2±38.0 °C(Predicted)
Dichte
1.048±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
Chloroform (Slightly), Ethyl Acetate (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
InChI
InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14?,16-,17+,18-,19-,20-,21+/m0/s1
InChIKey
XMRPGKVKISIQBV-CVHNGYJVSA-N
SMILES
C1(=O)CC2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@H](C(=O)C)CC3)CC2
CAS Datenbank
566-65-4(CAS DataBase Reference)
NIST chemische Informationen
3,20-Allopregnanedione(566-65-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. TU4157150
HS Code  2937.29.9095
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H312 Gesundheitssch?dlich bei Hautkontakt. Akute Toxizit?t dermal Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P280,P302+P352, P312, P322, P363,P501
H332 Gesundheitssch?dlich bei Einatmen. Akute Toxizit?t inhalativ Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P271, P304+P340, P312
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P312 Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P322 Gezielte Ma?nahmen
P330 Mund ausspülen.
P363 Kontaminierte Kleidung vor erneutem Tragen waschen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

5-α-Pregnan-3,20-dion Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(5α)-Pregnane-3,20-dione exerts neuroprotective effects in chronic autoimmune encephalomyelitis (EAE). The neuroactivity of the steroid acts as a therapeutic agent for multiple sclerosis.

Definition

ChEBI: 5alpha-pregnane-3,20-dione is a C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone. It has a role as a human metabolite and a progestogen. It is a 20-oxo steroid, a C21-steroid hormone and a 3-oxo-5alpha-steroid. It is functionally related to a progesterone. It derives from a hydride of a 5alpha-pregnane.

Biochem/physiol Actions

(5α)-Pregnane-3,20-dione is a high-level metabolite of progesterone in breast cancer tissue (but not normal breast tissue); promotes cell proliferation and detachment. Receptors appear only on the cell surface of MCF-7 breast cancer cells, not on nuclei where most other steroid receptors are located.

Biologische Aktivit?t

Digestive gland subcellular fractions readily converted P4 into 5-pregnane-3,20-dione and minor amounts of a second metabolite and then 5-pregnane-3,20-dione was further metabolized to 3-hydroxy-5-pregnane-20-one (3,20-one) by 3β-HSD. This reaction was significantly inhibited by trilostane which is a 3β-HSD inhibitor[1-2].

5-α-Pregnan-3,20-dion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

PREGNANEDIONE Progesteron

Downstream Produkte

Pregnan-20-one, 3-hydroxy-3-methyl-, (3β,5α)- GANAXOLONE Pregnan-20-one, (5alpha)-

5-α-Pregnan-3,20-dion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 168)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Pharmaceuticals Group Corp., Ltd. 		+8613004379774
 wu@jiaerke.com China 33 58
Wuhan Han Sheng New Material Technology Co.，Ltd
+8617798174412
 admin01@hsnm.com.cn China 2097 58
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050
 sean.lv@synzest.com China 323 58
Nantong Guangyuan Chemicl Co,Ltd 		+undefined17712220823
 admin@guyunchem.com China 615 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886
info@dakenam.com China 18751 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58

566-65-4(5-α-Pregnan-3,20-dion)Verwandte Suche:

  • ALLOPREGNANE-3,20-DIONE
  • ALLOPREGNAN-3,20-DIONE
  • ALLOPREGNANDIONE
  • (5S,8R,9S,10S,13S,14S,17S)-17-ACETYL-10,13-DIMETHYL-HEXADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
  • 5 A-PREGNANE-3 20-DIONE
  • 5A-PREGNAN-3,20-DIONE
  • 5ALPHA-PREGNANE-3,20-DIONE (ALLO)
  • 5ALPHA-DIHYDROPROGESTERONE
  • 5-ALPHA-PREGNAN-3,20-DIONE
  • 5A-DIHYDROPROGESTERONE
  • (5-alpha)-pregnane-20-dione
  • 3,20-Allopregnanedione
  • 3,20-Dioxo-5alpha-pregnane
  • 5alpha-Pregnane-3,20-dione
  • 5-beta-pregnane-3,20-dione
  • Pregnane-3,20-dione, (5alpha)-
  • 5A-pregnane-3-20-dione-allo
  • 5alpha-Pregnan-3,20-dione-1,2,4,5,6,7-D6
  • 5α-pregnane-3,20-dione (allo)
  • (5S,8R,9S,10S,13R,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
  • 4-07-00-02199 (Beilstein Handbook Reference)
  • 5 A-PREGNANE-3 20-DIONE 99%
  • 5α-Pregnan-3,20-dione-1,2,4,5,6,7-D6
  • 5α-Dihydroprogesterone, Allopregnane-3,20-dione
  • (5S,8R,9S,10S,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
  • Allopregnanedione
  • ALLOPREGNENDIONE(RG)(CALL)
  • 5α-Pregnane-3,20-dione (allo),5α-Dihydroprogesterone, Allopregnane-3,20-dione
  • Hydrogenated progesterone
  • 5alpha-Pregnane-3,20-dione (allo) progesterone metabolite
  • (8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
  • (8R,9S,10S,13S,14S,17S)-17-ethanoyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
  • 5-Alpha-Dihydro Progesterone-d8
  • Pregnane-3,20-dlone
  • Pregnane-3,20-dione, (5α)-
  • PREGNANE-3,20-DIONE CAS NO 566-65-4
  • 5-alpha-Dihydroprogesterone ISO 9001：2015 REACH
  • Estrone Impurity 23
  • 566-65-4 5-alpha-Dihydroprogesterone
  • Pregnane-3,20-dione
  • 5α-dihydroprogesterone
  • 5α-pregnane-3,20-dione
  • 5α-Dihydroprogesterone
  • 5a-Pregnane-3,20-Dione（Dihydroprogesterone）
  • (5S,8R,9S,10S,13S,14S,17S)-17-Acetyl-10,13-dimethyltetradecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
  • Pregnenolone Impurity 13
  • 5α-PREGNAN-3, 20-DIONE
  • 566-65-4
  • Steroids
  • 566-65-4
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