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b-AP15

b-AP15 Struktur
330450-45-8
CAS-Nr.
330450-45-8
Englisch Name:
b-AP15
Synonyma:
b-AP15;NSC-687852;NSC687852 >=98% (HPLC);(3Z,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-piperidin-4-one;4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-
CBNumber:
CB02667632
Summenformel:
C22H17N3O6
Molgewicht:
419.39
MOL-Datei:
330450-45-8.mol

b-AP15 Eigenschaften

Siedepunkt:
670.4±55.0 °C(Predicted)
Dichte
1.416±0.06 g/cm3(Predicted)
pka
-1.39±0.20(Predicted)

Sicherheit

b-AP15 Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This deubiquitinase inhibitor (FW = 421.31 g/mol; CAS 1009817-63-3), also named 3,5-bis[ (4-nitrophenyl) methylene]-1- (1-oxo-2-propen-1-yl) - (3E,5E) -4-piperidinone, targets two proteasome-associated ubiquitin carboxyl-terminal hydrolase-14, or USP14, and Ubiquitin Carboxyl-terminal Hydrolase isozyme L5 UCHL5, IC50 = 2.1 μM, resulting in a rapid accumulation of high-molecular-weight ubiquitin conjugates and functional shutdown of proteasome. Interestingly, b-AP15 displays several differences with respect to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in solid tumor models. Inhibition of DUBs blocked the processing and release of interleukin IL-1β in both mouse and human macrophages. DUB activity was necessary for inflammasome association as DUB inhibition also impaired ASC oligomerization and caspase-1 activation without directly blocking caspase- 1 activity. These data reveal the requirement for DUB activity in a key reaction of the innate immune response and highlight the therapeutic potential of DUB inhibitors for chronic auto-inflammatory diseases. (See also Bortezomib, Eeeyarestatin I)

b-AP15 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


b-AP15 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 55)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4861 58
SPIRO PHARMA
eric_feng1954@126.com China 9248 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
klq@cw-bio.com China 4963 55
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977
wj520wjxby@126.com China 1925 55
Shanghai Zeye Biotechnology Co., Ltd. 021-61998551 13122364865
sale1@shzysw.net China 9772 58
Chunchuang (Wuhan) Technology Co., Ltd 15342225168
yutianchun2007@126.com China 10003 58
Wuhan Yanzhe Technology Co., Ltd 15527250409
wenhaotian12@163.com China 4148 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44918 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 17771424646
shoubull@126.com China 970 58
bioleaper 4000880777 17585207275
guojing@bioleaper.com China 5616 58

  • b-AP15
  • NSC-687852
  • (3Z,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-piperidin-4-one
  • NSC687852 >=98% (HPLC)
  • 4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-
  • 330450-45-8
  • 1009817-63-4
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