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ChemicalBook >> CAS DataBase List >>b-AP15

b-AP15

CAS No.
330450-45-8
Chemical Name:
b-AP15
Synonyms
b-AP15;NSC-687852;NSC687852 >=98% (HPLC);(3Z,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-piperidin-4-one;4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-
CBNumber:
CB02667632
Molecular Formula:
C22H17N3O6
Molecular Weight:
419.39
MDL Number:
MFCD25976718
MOL File:
330450-45-8.mol

b-AP15 Properties

Boiling point 670.4±55.0 °C(Predicted)
Density 1.416±0.06 g/cm3(Predicted)
pka -1.39±0.20(Predicted)

b-AP15 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 4566 NSC687852 ≥97%(HPLC) 330450-45-8 10 $149 2021-12-16 Buy
Tocris 4566 NSC687852 ≥97%(HPLC) 330450-45-8 50 $549 2021-12-16 Buy
Usbiological 256062 NSC 687852 330450-45-8 10mg $403 2021-12-16 Buy
Ark Pharm P000532871 b-AP15 98+% 330450-45-8 100mg $509 2021-12-16 Buy
Ark Pharm P000532871 b-AP15 98+% 330450-45-8 250mg $814 2021-12-16 Buy
Product number Packaging Price Buy
4566 10 $149 Buy
4566 50 $549 Buy
256062 10mg $403 Buy
P000532871 100mg $509 Buy
P000532871 250mg $814 Buy

b-AP15 Chemical Properties,Uses,Production

Enzyme inhibitor

This deubiquitinase inhibitor (FW = 421.31 g/mol; CAS 1009817-63-3), also named 3,5-bis[ (4-nitrophenyl) methylene]-1- (1-oxo-2-propen-1-yl) - (3E,5E) -4-piperidinone, targets two proteasome-associated ubiquitin carboxyl-terminal hydrolase-14, or USP14, and Ubiquitin Carboxyl-terminal Hydrolase isozyme L5 UCHL5, IC50 = 2.1 μM, resulting in a rapid accumulation of high-molecular-weight ubiquitin conjugates and functional shutdown of proteasome. Interestingly, b-AP15 displays several differences with respect to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in solid tumor models. Inhibition of DUBs blocked the processing and release of interleukin IL-1β in both mouse and human macrophages. DUB activity was necessary for inflammasome association as DUB inhibition also impaired ASC oligomerization and caspase-1 activation without directly blocking caspase- 1 activity. These data reveal the requirement for DUB activity in a key reaction of the innate immune response and highlight the therapeutic potential of DUB inhibitors for chronic auto-inflammatory diseases. (See also Bortezomib, Eeeyarestatin I)

b-AP15 Preparation Products And Raw materials

Raw materials

Preparation Products

b-AP15 Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
SPIRO PHARMA eric_feng1954@126.com China 9248 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 4966 55
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1925 55
Shanghai Zeye Biotechnology Co., Ltd. 021-61998551 13122364865 sale1@shzysw.net China 9772 58
Chunchuang (Wuhan) Technology Co., Ltd 15342225168 yutianchun2007@126.com China 10003 58
Wuhan Yanzhe Technology Co., Ltd 15527250409 wenhaotian12@163.com China 4148 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44918 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 17771424646 shoubull@126.com China 970 58
bioleaper 4000880777 17585207275 guojing@bioleaper.com China 5616 58
b-AP15 NSC-687852 (3Z,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-piperidin-4-one NSC687852 >=98% (HPLC) 4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)- 330450-45-8 1009817-63-4