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AVL-292

AVL-292 Struktur
1202757-89-8
CAS-Nr.
1202757-89-8
Englisch Name:
AVL-292
Synonyma:
CC-292;CS-733;LMK-435;AVL-292;Spebrutinib;AVL-292 >=98%;CC-292,LMK-435;CC-292 (AVL-292);AVL 292 - CC 292;AVL-292 USP/EP/BP
CBNumber:
CB02655392
Summenformel:
C22H22FN5O3
Molgewicht:
423.44
MOL-Datei:
1202757-89-8.mol

AVL-292 Eigenschaften

Dichte
1.322±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic
Aggregatzustand
solid
pka
13.22±0.70(Predicted)
Farbe
White to khaki
CAS Datenbank
1202757-89-8

Sicherheit

AVL-292 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]

AVL-292 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


AVL-292 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 156)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Zhejiang ZETian Fine Chemicals Co. LTD
+8618957127338
stella@zetchem.com China 2136 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 965 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58

  • AVL-292
  • LMK-435
  • N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide
  • 2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
  • CC-292 (AVL-292)
  • CC-292,LMK-435
  • N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide AVL292
  • CC-292
  • Spebrutinib
  • AVL-292 (Spebrutinib)
  • AVL-292 >=98%
  • N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide
  • N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide
  • CS-733
  • N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide (AVL-292)
  • CC-292; AVL292; AVL-292; AVL 292
  • AVL 292 - CC 292
  • CC-292;AVL292;AVL-292;AVL 292;SPEBRUTINIB
  • Spebrutinib (AVL-292)
  • Spebrutinib (CC-292, AVL-292)
  • N-{3-[(5-Fluoro-2-{[4-(2-methoxyethoxy)phenyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide
  • AVL-292 USP/EP/BP
  • Spebrutinib (CC292
  • 7-Epoxytropine hydrochloride
  • 1202757-89-8
  • Inhibitors
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