80508-81-2
基本信息
藍萼乙素 B
藍萼乙素對照品
藍萼乙素標準品
glaucocalyxin B
14beta-Acetoxy-7alpha-hydroxy-ent-kaur-16-ene-3,15-dione
Kaur-16-ene-3,15-dione, 14-(acetyloxy)-7-hydroxy-, (7α,14R)-
物理化學性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-N2113 | 藍萼乙素 Glaucocalyxin B | 80508-81-2 | 1mg | 2000元 |
2024/11/08 | HY-N2113 | 藍萼乙素 Glaucocalyxin B | 80508-81-2 | 10 mM * 1 mLin DMSO | 3620元 |
2024/11/08 | HY-N2113 | 藍萼乙素 Glaucocalyxin B | 80508-81-2 | 5mg | 4400元 |
常見問題列表
IC50: 5.86 μM (HL-60 cell Growth)
Glaucocalyxin A (GlnA) and (GlnB) dose-dependently decrease the growth of HL-60 cells with an IC 50 of approximately 6.15 and 5.86 μM at 24 h, respectively. Both Gln A and B could induce apoptosis, G2/M-phase cycle arrest, DNA damage and the accumulation of reactive oxygen species (ROS) in HL-60 cells. GlnB inhibits the proliferation of human cervical cancer cells in vitro through the induction of apoptosis andautophagy, which may be mediated by the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway. Treatment with GlnB inhibits the proliferation of HeLa and SiHa cervical cancer cell lines in a dose dependent manner. GlnB increases the apoptotic cell population of and enhanced poly (ADP ribose) polymerase 1 cleavage. GlnB also induces increased light chain 3 II/I protein cleavage, indicating the induction of autophagy. GlnB treatment increases the expression of phosphatase and tensin homolog and decreases the expression of phosphorylated protein kinase B. Glaucocalyxin B (GLB), one of five ent-kauranoid diterpenoids, significantly decreased the generation of nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-activated microglia cells.