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80508-81-2

中文名稱 藍萼乙素
英文名稱 glaucocalyxin B
CAS 80508-81-2
分子式 C22H30O5
分子量 374.48
MOL 文件 80508-81-2.mol
更新日期 2024/05/10 09:12:19
80508-81-2 結(jié)構(gòu)式 80508-81-2 結(jié)構(gòu)式

基本信息

中文別名
藍萼乙素
藍萼乙素 B
藍萼乙素對照品
藍萼乙素標準品
英文別名
Wangzaozin C
glaucocalyxin B
14beta-Acetoxy-7alpha-hydroxy-ent-kaur-16-ene-3,15-dione
Kaur-16-ene-3,15-dione, 14-(acetyloxy)-7-hydroxy-, (7α,14R)-
所屬類別
生物化工:植物提取物

物理化學性質(zhì)

外觀性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機溶劑,來源于唇形科植物藍萼香茶菜Rabdosia japonica 全草,冬凌草。
熔點190.5-191℃
沸點509.1±50.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)13.42±0.70(Predicted)
形態(tài)Solid
顏色White to off-white

應(yīng)用領(lǐng)域

用途1
藍萼乙素具有抗血小板聚集,抑制癌細胞的作用。
藍萼乙素價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-N2113藍萼乙素
Glaucocalyxin B
80508-81-21mg2000元
2024/11/08HY-N2113藍萼乙素
Glaucocalyxin B
80508-81-210 mM * 1 mLin DMSO3620元
2024/11/08HY-N2113藍萼乙素
Glaucocalyxin B
80508-81-25mg4400元

常見問題列表

生物活性
Glaucocalyxin B是從中藥香茶菜中分離出來的對映-貝殼杉烷型二萜,具有抗癌和抗炎活性。 24h內(nèi)減少HL-60 生長的IC50值約為5.86 μM。
靶點

IC50: 5.86 μM (HL-60 cell Growth)

體外研究

Glaucocalyxin A (GlnA) and (GlnB) dose-dependently decrease the growth of HL-60 cells with an IC 50 of approximately 6.15 and 5.86 μM at 24 h, respectively. Both Gln A and B could induce apoptosis, G2/M-phase cycle arrest, DNA damage and the accumulation of reactive oxygen species (ROS) in HL-60 cells. GlnB inhibits the proliferation of human cervical cancer cells in vitro through the induction of apoptosis andautophagy, which may be mediated by the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway. Treatment with GlnB inhibits the proliferation of HeLa and SiHa cervical cancer cell lines in a dose dependent manner. GlnB increases the apoptotic cell population of and enhanced poly (ADP ribose) polymerase 1 cleavage. GlnB also induces increased light chain 3 II/I protein cleavage, indicating the induction of autophagy. GlnB treatment increases the expression of phosphatase and tensin homolog and decreases the expression of phosphorylated protein kinase B. Glaucocalyxin B (GLB), one of five ent-kauranoid diterpenoids, significantly decreased the generation of nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-activated microglia cells.

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