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24268-41-5

中文名稱 莪術(shù)呋喃二烯酮
英文名稱 Furanodienone
CAS 24268-41-5
分子式 C15H18O2
分子量 230.3
MOL 文件 24268-41-5.mol
更新日期 2024/12/20 18:42:49
24268-41-5 結(jié)構(gòu)式 24268-41-5 結(jié)構(gòu)式

基本信息

中文別名
呋喃二烯酮
莪術(shù)環(huán)二烯酮
莪術(shù)呋喃二烯酮
莪術(shù)呋喃二烯酮對(duì)照品
莪術(shù)呋喃二烯酮標(biāo)準(zhǔn)品
呋喃二烯酮,蓬莪術(shù)環(huán)二烯酮
英文別名
Furanodienon
Furanodienone
(1E,4E)-8,12-Epoxygermacra-1(10),4,7,11-tetraen-6-one
(5Z)-3,6,10-trimethyl-8,11-dihydrocyclodeca[b]furan-4(7H)-one
(5E,9E)-8,11-Dihydro-3,6,10-trimethylcyclodeca[b]furan-4(7H)-one
Cyclodeca[b]furan-4(7H)-one, 8,11-dihydro-3,6,10-trimethyl-, (5E,9E)-
所屬類別
生物化工:植物提取物

物理化學(xué)性質(zhì)

外觀性狀來(lái)源于莪術(shù)
熔點(diǎn)83-84℃
沸點(diǎn)89.5-90.5 °C
密度1.022±0.06 g/cm3(Predicted)
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
形態(tài)粉末
顏色White to off-white
LogP2.654 (est)

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。

常見問(wèn)題列表

生物活性
Furanodienone 是源自姜黃根莖 Rhizoma Curcumae 的主要生物活性成分之一。Furanodienone 誘導(dǎo)細(xì)胞凋亡 (apoptosis)。
體外研究

Furanodienone (0-573.8?μM; 24? hours) exhibits IC 50 values : 56.4?μM (RKO), 73.7?μM (sw480), 251.1?μM (HT-29), 412.5?μM (sw620) and 573.8?μM (LoVo) at 24 hours, while that in 48?h are 51.8?μM (RKO), 44.18?μM (sw480), 168.9?μM (HT-29), 314.2?μM (sw620) and 502.1?μM (LoVo), respectively. Furanodienone (0-150 μM; 24? hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells. Furanodienone (0-150?μM; 24 ?hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150?μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150?μM are observed in HT-29 cells compared with 2.89±0.26%.

Western Blot Analysis

Cell Line: RKO and HT-29 cells
Concentration: 0 μM; 50 μM; 100 μM; 150 μM
Incubation Time: 24 hours
Result: Increased caspase-9 and -3.

Apoptosis Analysis

Cell Line: RKO and HT-29 cells
Concentration: 0 μM; 75 μM; 150 μM
Incubation Time: 24 hours
Result: Induced apoptosis of colorectal cells (RKO and HT-29).
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