74764-40-2
中文名稱
鹽酸芐普地爾
英文名稱
Bepridil hydrochloride
CAS
74764-40-2
分子式
C24H37ClN2O2
分子量
421.016
MOL 文件
74764-40-2.mol
更新日期
2024/12/23 10:32:57
74764-40-2 結(jié)構(gòu)式
基本信息
中文別名
鹽酸芐普地爾芐普地爾鹽酸鹽
芐普地爾鹽酸鹽水合物
1-異丁氧基-2-吡咯烷基-3-(N-芐基苯胺基)丙烷鹽酸鹽
化合物 BEPRIDIL HYDROCHLORIDE HYDRATE
英文別名
angoprilUnii-4W2p15D93m
Bepridil hydrochloride
UEECHQPWQHYEDE-UHFFFAOYSA-N
Bepridil hydrochloride salt
Bepridil hydrochloride hydrate
Bepridil hydrochloride USP/EP/BP
l)-,monohydrochloride,monohydrate
1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride
N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)anilinehydrochloride
所屬類別
原料藥：防治心絞痛藥物理化學(xué)性質(zhì)
熔點(diǎn)91 ±2°
儲存條件Desiccate at RT
溶解度Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)
形態(tài)powder
顏色white
穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
安全數(shù)據(jù)
警示詞危險
危險性描述H317-H332-H334
WGK Germany2
RTECS號UY1162000
毒性LD50 in mice (mg/kg): 1955 orally, 23.5 i.v. (Mauvernay, 1978)
常見問題列表
生物活性
Bepridil hydrochloride是一種抗心絞痛的藥物，是鈣離子通道（calcium channel）阻滯劑。它能阻止多種其他離子通道，包括鈉離子和鉀離子通道。靶點(diǎn)
|
Ca 2+
|
體外研究
Bepridil hydrochloride hydrate blockades of Ca
2+
-dependent action potentials in vascular smooth muscle of dog coronary artery.
Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC
50
s of 0.5 μM and 30 μM, respectively in cultured ventricular cells.
Bepridil hydrochloride hydrate decreases I
Ks
under blockade of I
Kr
with E4031 (5 μM), in a concentration-dependent manner.
體內(nèi)研究
Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration.