67884-30-4
中文名稱
石斛酚
英文名稱
Dendrophenol
CAS
67884-30-4
分子式
C16H18O4
分子量
274.31
MOL 文件
67884-30-4.mol
更新日期
2024/12/26 09:13:32
67884-30-4 結(jié)構(gòu)式
基本信息
中文別名
石斛酚標(biāo)準(zhǔn)品 英文別名
Phenol, 5-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxy-Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol)
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
外觀性狀類白色結(jié)晶體，易溶于甲醇、乙酸乙酯，幾乎不溶于水，來源于金釵石斛。
沸點(diǎn)454.1±40.0 °C(Predicted)
密度1.204±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : ≥ 160 mg/mL (583.28 mM)
酸度系數(shù)(pKa)9.63±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Gigantol是一種來自幾種藥用蘭花的聯(lián)芐基化合物。 Gigantol 具有抗腫瘤活性。Gigantol 是 Wnt/β-catenin 通路的抑制劑。靶點(diǎn)
Wnt
體外研究
Gigantol decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduces the level of phosphorylated LRP6. Gigantol significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. Gigantol at concentrations of 1, 40 and 150 μM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC 50 value is 9.30 μM.
體內(nèi)研究
LDD and gigantol (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats.