535-83-1
基本信息
葫蘆巴堿
煙酸甜菜堿
N-甲菸鹼酸內(nèi)鹽
菸鹼酸N-甲內(nèi)鹽
葫蘆巴堿(標(biāo)準(zhǔn)品)
葫蘆巴堿, 來(lái)源于葫蘆巴
1-甲基吡啶-3-甲酸內(nèi)鹽
1-甲基吡啶鎓-3-甲酸內(nèi)鹽
TRIGONELLINE 葫蘆巴堿
Gynesine
Coffearin
Coffearine
Caffearine
Trigonellin
Trigoneline
Trigenolline
TRIGONELLINE
betainnicotinate
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
Target | Value |
PLCγ1
() | |
PI3K
() | |
Akt
() | |
microtubule
() |
It is found that Trigonelline (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirms that Trigonelline significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .
Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.