66803-19-8
66803-19-8 結(jié)構(gòu)式
基本信息
相模霉素
沙加霉素
硫酸小諾米星
硫酸小諾霉素
硫酸相模霉素
硫酸沙加霉素
小諾霉素(標準品)
硫酸小諾米星/硫酸沙加霉素
硫酸小諾霉素,沙加霉素,硫酸小諾米星
MICRONOMICIN SULFATE
sulfate,d-1-6))-2-deoxy
Micronomicin Sulfate (~80%)
Micronomicin sulfate JAS1998
MICRONOMICIN SULFATE USP/EP/BP
Micronomicin Sulfate CAS: 66803-19-8
6'-N-METHYLGENTAMICIN C1A HEMIPENTASULFATE
streptamine,o-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-d-erythro-hexop
yranosyl-(1-4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(
物理化學性質(zhì)
應(yīng)用領(lǐng)域
常見問題列表
MIC: 0.001-8.3 μg/ml ( Pseudomonas , Proteus , Klebsiella pneumoniae , Serratia )
Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml).
Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD 50 in mice of 93 mg/kg.Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over.
| Animal Model: | Wistar rats |
| Dosage: | 4, 10, 25, 63 mg/kg and 100 mg/kg |
| Administration: | Intravenous injection; 30 days |
| Result: | Led to death of rat at 100 mg/kg. |