55319-36-3
中文名稱
大豆皂苷II
英文名稱
(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9S,12aR,14aS,14bR)-9-hydro xy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8 ,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[(2S,3R,4S,5S)-4,5 -dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy -oxan-2-yl]oxy-3,4-dihydroxy-oxane-2-carboxylic acid
CAS
55319-36-3
分子式
C47H76O17
分子量
913.1
MOL 文件
55319-36-3.mol
更新日期
2025/01/10 09:25:19
55319-36-3 結(jié)構(gòu)式
基本信息
中文別名
大豆皂苷II大豆皂苷BC,大豆皂苷II
英文別名
Soysaponin IISoybean saponin Bc
Soyasaponin II(Soyasaponin Bc,Soyasaponin B-II,Soysaponin II)
3-O-[α-L-rhamnopyranosyl(1->2)-α-L-arabinopyranosyl-(1->2)-β-D-glucuronopyranosyl]soyasaponin B
(4S)-3β-[2-O-[2-O-(α-L-Rhamnopyranosyl)-α-L-arabinopyranosyl]-β-D-glucurono pyranosyloxy]oleana-12-ene-22β,24-diol
[(4S)-22β,23-Dihydroxyolean-12-en-3β-yl]2-O-[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]-β-D-glucopyranosiduronic acid
β-D-Glucopyranosiduronic acid, (3β,4β,22β)-22,23-dihydroxyolean-12-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-α-L-arabinopyranosyl-(1→2)-
(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9S,12aR,14aS,14bR)-9-hydro xy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8 ,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[(2S,3R,4S,5S)-4,5 -dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy -oxan-2-yl]oxy-3,4-dihydroxy-oxane-2-carboxylic acid
所屬類別
生物化工：植物提取物常見問題列表
生物活性
Soyasaponin II 是具有抗病毒活性的皂苷。Soyasaponin II 抑制 HSV-1，HCMV，流感病毒和 HIV-1 的復(fù)制。Soyasaponin II 對(duì) HSV-1 復(fù)制顯示出有效的抑制作用。Soyasaponin II 作為 YB-1 磷酸化和 NLRP3 炎性小體引發(fā)的抑制劑，可保護(hù)小鼠免受 LPS/GalN 誘導(dǎo)的急性肝衰竭。靶點(diǎn)
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HSV-1 54 μM (IC 50 ) |
HIV-1 112 μM (IC 50 ) |
influenza virus 88 μM (IC 50 ) |
HCMV 104 μM (IC 50 ) |
NLRP3 inflammasome
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體外研究
Soyasaponin II inhibits the replication of HSV-1 (IC 50 =54μM), HCMV (104μM), influenza virus (88μM), and HIV-1 (112 μM).
體內(nèi)研究
Soyasaponin II (5 mg/kg; p.o.; once a day for three consecutive days) ameliorates canonical NLRP3 inflammasome-associated innate immune response.