51276-47-2
51276-47-2 結(jié)構(gòu)式
基本信息
中文別名
草氨瞵 英文別名
C05042HOE-866
HOE-35956
Phosphinothricin
IAJOBQBIJHVGMQ-UHFFFAOYSA-N
Phosphinothricin ammonium salt
2-amino-4-(hydroxymethylphosphinyl)butyric acid
2-Amino-4-(methylhydroxyphosphinyl)butyric acid
物理化學(xué)性質(zhì)
熔點(diǎn)229-231° (dec)
沸點(diǎn)519.1±45.0 °C(Predicted)
密度1.378±0.06 g/cm3(Predicted)
溶解度Aqueous Acid (Slightly), Methanol (Very Slightly, Sonicated), Water (Slightly)
酸度系數(shù)(pKa)2.22±0.10(Predicted)
形態(tài)固體
顏色白色至淺米色
穩(wěn)定性吸濕性
LogP-0.750 (est)
EPA化學(xué)物質(zhì)信息Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)- (51276-47-2)
常見(jiàn)問(wèn)題列表
生物活性
Glufosinate 是谷氨酸的膦酸類似物，是一種由植物細(xì)胞轉(zhuǎn)化為 PT (L-phosphinothricin) 的除草劑。Glufosinate 具有神經(jīng)毒性作用。體外研究
Glufosinate (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs).
Glufosinate (1-100 μM; 12DIV) significantly decreases
Celsr2
gene expression at 100 μM.
Glufosinate impairs ependymal cell capability to synthetize cilia.
體內(nèi)研究
Glufosinate (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats.
The Elimination of Glufosinate (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats.