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482-45-1

中文名稱 異歐前胡素
英文名稱 Isoimperatorin
CAS 482-45-1
分子式 C16H14O4
MDL 編號(hào) MFCD00272155
分子量 270.28
MOL 文件 482-45-1.mol
更新日期 2024/12/20 18:41:58
482-45-1 結(jié)構(gòu)式 482-45-1 結(jié)構(gòu)式

基本信息

中文別名
異歐前胡素
白芷甲素
異歐芹屬素乙
4-(3-甲基丁-2-烯氧基)呋喃并[3,2-g]苯并吡喃-7-酮
英文別名
4-PRENYLOXYPSORALEN
ISOIMPERATORIN
4-(3-Methyl-but-2-enyloxy-furo[3,2-g]chromen-7-one
ISOIMPERATORIN(P)
Isomperatorin
4-(3-Methylbut-2-enoxy)furo[3,2-g]chromen-7-one
4-(3-Methyl-but-2-enyloxy-furo[3,2-γ],chromen-7-one
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-
buten-1-yl)oxy]-
4-(Isopentenyloxy)-7H-furo[3,2-g][1]benzopyran-7-one
4-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one
Isoimperatoin
所屬類別
生物化工:中草藥成分

物理化學(xué)性質(zhì)

外觀性狀來源于大風(fēng)子科羅旦梅 Flacourtiajangomas(Lour.)Raeusch莖,皮
熔點(diǎn)107-111°C
沸點(diǎn)448.3±45.0 °C(Predicted)
密度1.242±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度可溶于氯仿(少量)、乙酸乙酯(少量
形態(tài)neat
顏色白色至淡黃色
BRN1291723
LogP3.495 (est)
CAS 數(shù)據(jù)庫(kù)482-45-1(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H317-H335
安全說明24/25
WGK Germany3
RTECS號(hào)LV1513000
海關(guān)編碼29329990
毒害物質(zhì)數(shù)據(jù)482-45-1(Hazardous Substances Data)

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。

常見問題列表

藥理作用
分子式C16H14O4,分子量270.27,無色針狀結(jié)晶(乙醇),熔點(diǎn)110~111℃。
異歐前胡素具有降壓、解痙、抗癌的作用,還可以治療銀屑病。
羌活中異歐前胡素的含量測(cè)定
[色譜條件]
色譜柱:μbondapak C18柱(150mm×6mm, 5μm);流動(dòng)相:甲醇-乙腈-0.25mol/L磷酸溶液(9:5:10);流速:1.0ml/min;檢測(cè)波長(zhǎng):322nm;柱溫:室溫。
[供試品的制備]
取本品粗粉約50g,用8倍量90%乙醇回流提取3次,每次1.5h,合并提取液,回收乙醇,得浸膏13.70g,并將其與適量經(jīng)處理過的大孔吸附樹脂拌勻,置于經(jīng)處理過的大孔吸附樹脂柱上,依次用水,20%、30%、40%、50%、60%、70%、80%、90%的乙醇沖洗,每次沖至洗脫液無色,水浴蒸干,得膏狀物,分別用50%乙醇溶解,定容至50ml。按本法色譜條件進(jìn)行測(cè)定。
生物活性
Isoimperatorin 是Angelica dahurica 根的甲醇提取物,有效抑制乙酰膽堿酯酶 (AChE),IC50 為 74.6 μM。
靶點(diǎn)
TargetValue
AChE
(Cell-free assay)
74.6 μM
體外研究

During a screening program for new agrochemicals from Chinese medicinal herbs, the ethanol extract of Notopterygium incisum rhizomes is found to possess strong nematicidal activity against the two species of nematodes, Bursaphelenchus xylophilus and Meloidogyne incognita . Based on bioactivity-guided fractionation, the four constituents are isolated from the ethanol extract and identified as Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin. Isoimperatorin also has LC 50 values of 21.83 μg/mL against B. xylophilus . When using 15 min UV light treatment, falcarindiol, falcarinol, and isoimperatorin demonstrated almost five times more toxic to the southern root-knot nematodes than in dark treatment while columbianetin showed only two times more toxic. isoimperatorin has been demonstrated to possess insecticidal activity against several insects, such as the cabbage aphid ( Brevicoryne brassicae ). Isoimperatorin is identified in the active fraction of Angelica dahurica (AD) extract. Isoimperatorin is usually used as the internal standard (IS).

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