4192-90-9
中文名稱
三葉苷
英文名稱
PRUNINDIHYDROCHALCONE
CAS
4192-90-9
分子式
C21H24O10
分子量
436.41
MOL 文件
4192-90-9.mol
更新日期
2024/12/17 08:54:10
4192-90-9 結(jié)構(gòu)式
基本信息
中文別名
三葉苷三葉甙
P-根皮苷
三葉苷(標(biāo)準(zhǔn)品)
三葉苷, 來(lái)源于甜茶
TRILOBATIN標(biāo)準(zhǔn)品
英文別名
Trilobatinp-Phlorizin
p-Phloridzin
TRILOBATIN(SH)
PRUNINDIHYDROCHALCONE
Phloretin 4'-glucoside
Trilobatin, 98%, from leaf of strigose hydrangea
1-[4-(β-D-Glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
1-Propanone, 1-[4-(β-D-glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
1-[2,6-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one
所屬類別
天然產(chǎn)物：查爾酮類化合物物理化學(xué)性質(zhì)
外觀性狀可溶于甲醇、乙醇、DMSO等有機(jī)溶劑。
熔點(diǎn)170-173 °C
沸點(diǎn)787.9±60.0 °C(Predicted)
密度1.555±0.06 g/cm3(Predicted)
儲(chǔ)存條件4°C, protect from light
溶解度DMF: 20 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.1 mg/ml
酸度系數(shù)(pKa)6.85±0.40(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
JECFA Number2171
LogP1.36
常見(jiàn)問(wèn)題列表
生物活性
Trilobatin 是一種甜味劑，源自 Lithocarpus polystachyus?Rehd，Trilobatin 是一種 HIV-1 抑制劑，靶向 Gp41 包膜蛋白。具有神經(jīng)保護(hù)作用。Trilobatin 還是 SGLT1/2 抑制劑，可選擇性誘導(dǎo)人肝母細(xì)胞瘤細(xì)胞增殖。靶點(diǎn)
| Target | Value |
|
HIV-1 entry
() |
體外研究
Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway.