40391-99-9
40391-99-9 結(jié)構(gòu)式
基本信息
帕屈膦酸
伊班膦酸雜質(zhì)5
帕米膦酸及帕米膦酸鈉
(3-氨基-1-羥基亞丙基)雙膦酸
3-氨基-1-羥基-1,1-丙烷二膦酸
3-氨基-1-羥基丙亞基-1,1-二磷酸
(3-氨基-1-羥基丙烷-1,1-二基)二膦酸
AHPrBP
Panolin
amidronate
Rescriptor
Pamidronicaci
PAMIDRONIC ACID
Iflab-bb F1977-0047
Delavirdine mesylate
Ibandronate Impurity 23
物理化學(xué)性質(zhì)
帕米膦酸二鈉(Pamidronate Disodium)：C3H9NO7P2Na2?5H2O。[57248-88-1]。失水溫度從77.5℃到239.31℃，失水量為24．65%。
應(yīng)用領(lǐng)域
制備方法
帕米膦酸懸浮于水，滴加30%氫氧化鈉至Ph值7.2—7.4。-5-5℃冷置析晶，過濾。濾餅加適量蒸餾水，加熱溶解，活性炭脫色，冷凍結(jié)晶，過濾，室溫真空干燥至恒重，得帕米膦酸二鈉五水合物，收率78.6%。
常見問題列表
Wnt, β-catenin
Osteosarcoma cell viability decreases significantly in a concentration- and time-dependent manner at pamidronate concentrations ranging from 100 to 1000 μM, most consistently after 48 and 72 hours' exposure. In treated osteosarcoma cells, the lowest percentage cell viability is 34% (detected after 72 hours' exposure to 1000μM pamidronate). Pamidronate disodium inhibits Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reverses the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs.
Pamidronic acid can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration. The mechanisms involved may be associated with the upregulation of OPG expression, and downregulation of RANKL, MMP-9 and TLR-4 expression.