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基本信息
舒更葡糖鈉
蘇格瑪酯鈉鹽
舒更葡糖鈉雜質(zhì)
舒更葡糖鈉雜質(zhì)全套
舒更葡糖鈉(API)
舒更葡糖鈉標(biāo)準(zhǔn)品001
SUGAMMADEX 鈉鹽
SUGAMMADEX SODIUM舒更葡糖鈉
SUGAMMADEX SODIUM[干冰運(yùn)輸]
CS-2749
Sugammadex Na
Sugammadex IMP
Glucose-sodium
Sugammadex sodico
Sugammdaex sodium
Sugammadex Sudium
Sugammadex soidum
ORG-25969/SugaMMadex
物理化學(xué)性質(zhì)
常見問題列表
舒更葡糖鈉(Sugammadex Sodium Injection),商品名為布瑞亭(Bridion),是由默沙東公司開發(fā)的全球首個(gè)和唯一的特異性結(jié)合性神經(jīng)肌肉阻滯拮抗藥物。它是一種經(jīng)修飾的γ-環(huán)糊精,通過與神經(jīng)肌肉阻滯藥物羅庫溴銨或維庫溴銨在血漿中形成復(fù)合物,進(jìn)而降低在神經(jīng)肌肉接頭處與煙堿受體相結(jié)合的神經(jīng)肌肉阻滯藥物的數(shù)量,由此拮抗由羅庫溴銨或維庫溴銨誘導(dǎo)的神經(jīng)肌肉阻滯。
步驟1:活性炭的預(yù)處理
氮?dú)獗Wo(hù)下,取白鷺A(SHIRASAGIA)活性炭5克,100ml純化水加入至250ml三口瓶中,三口瓶配機(jī)械攪拌、接真空裝置。攪拌下,抽真空后通氮?dú)庵脫Q,保持氮?dú)夥諊?,將瓶?nèi)水/活性炭混合物加熱至沸騰。保持沸騰0.5小時(shí)后,停止加熱,降溫至室溫。氮?dú)鈮簽V,得到的濾餅為預(yù)處理后的活性炭,充氮封存待用。
步驟2:舒更葡糖鈉粗品的純化
將舒更葡糖鈉粗品10g,加入250ml三口瓶,溶于50ml新沸放冷水中,氮?dú)獗Wo(hù)下,加入實(shí)施例1制備得到的預(yù)處理后的特制白鷺(TOKUSEI SHIRASAGI)活性炭1g,攪拌吸附2小時(shí)。濾除活性炭,得到的水溶液經(jīng)濃縮后,得到舒更葡糖鈉純品9.2g,純度100.0%(舒更葡糖鈉+單羥基舒更葡糖鈉)。
Injection of sugammadex has no significant effects on blood pressure or heart rate. After injection of the high rocuronium dose, the 90% recovery of the train-of-four ratio takes 28 min (SD 7 min) after saline, 26 min (SD 9.5 min) after 1 mg/kg sugammadex, and 8 min (SD 3.6 min) after 2.5 mg/kg sugammadex. Sugammadex causes a rapid and complete reversal of rocuronium-induced neuromuscular block. The recovery time to train of four ratio=0.9 after spontaneous recovery is 14.4 min (SD=3.4 min; n=14). This is reduced significantly to 3.7 min (SD=3.3 min; n=4) with sugammadex 0.5 mg/kg and to 1.9 min (SD=1.0 min; n=4) with sugammadex 1.0 mg/kg. The estimated half-life of sugammadex in Rhesus monkey is 30 (SEM=4.9) min.