303126-97-8
中文名稱
303126-97-8
英文名稱
SR 0987
CAS
303126-97-8
分子式
C16H10ClF6NO2
分子量
397.7
MOL 文件
303126-97-8.mol
更新日期
2024/06/25 17:15:56
303126-97-8 結(jié)構(gòu)式
基本信息
中文別名
化合物SR0987 英文別名
SR 0987SR0987 >=98% (HPLC)
SR 0987
SR-0987
SR0987
303126-97-8
2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)378.8±42.0 °C(Predicted)
密度1.525±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Store in freezer, under -20°C
溶解度可溶于DMSO(至少25mg/ml)和乙醇(至少25mg/ml)
酸度系數(shù)(pKa)9.22±0.15(Predicted)
形態(tài)固體
顏色白色
穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
303126-97-8價(jià)格(試劑級(jí))
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-101454 | 303126-97-8 SR0987 | 303126-97-8 | 5mg | 800元 |
2024/11/08 | HY-101454 | 303126-97-8 SR0987 | 303126-97-8 | 10mM * 1mLin DMSO | 880元 |
2024/11/08 | HY-101454 | 303126-97-8 SR0987 | 303126-97-8 | 10mg | 1400元 |
常見(jiàn)問(wèn)題列表
生物活性
SR 0987 是一種SR 1078的類似物,是 T cell-specific RORγ (RORγt) 的激動(dòng)劑,EC50值為800 nM。SR 0987 可抑制 PD-1,生成 IL17,并具有治療癌癥的潛力。靶點(diǎn)
Target | Value |
PD-1
() | |
IL17
() | |
RORγt
(Cell-free assay) | 800 nM(EC50) |
體外研究
SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC 50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production.