2552-55-8
中文名稱
鵝膏氨酸
英文名稱
IBOTENIC ACID
CAS
2552-55-8
分子式
C5H6N2O4
MDL 編號(hào)
MFCD00069294
分子量
158.11
MOL 文件
2552-55-8.mol
更新日期
2024/05/28 16:04:20
2552-55-8 結(jié)構(gòu)式
基本信息
中文別名
鵝膏氨酸鵝膏蕈氨酸
英文別名
ALPHA-AMINO-3-HYDROXY-5-ISOOXAZOLACETIC ACID(+/-)ALPHA-AMINO-3-HYDROXY-5-ISOXAZOLEACETIC ACID
ALPHA-AMINO-3-HYDROXY-5-ISOXAZOLEACETIC ACID
ALPHA-AMINO-(3-HYDROXY-5-ISOXAZOLYL)ACETIC ACID
(+/-)-IBOTENIC ACID
IBOTENIC ACID
α-amino-3-hydroxy-5-isoxazoleacetic acid
DL-Ibotenic acid.
IBOTENIC ACID(RG)
5-Isoxazoleaceticacid,-alpha--amino-2,3-dihydro-3-oxo-(9CI)
alpha-Amino-(3-hydroxy-5-isoxazolyl)actetic acid
所屬類別
生物化工:常見(jiàn)氨基酸及蛋白質(zhì)類物理化學(xué)性質(zhì)
熔點(diǎn)141-147 °C
熔點(diǎn)141-147 °C
密度1.621±0.06 g/cm3 (20 ºC 760 Torr)
儲(chǔ)存條件-20°C
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度H2O:可溶,1mg/mL,透明,無(wú)色(超聲處理)
酸度系數(shù)(pKa)2.16±0.10(Predicted)
形態(tài)白色固體
顏色白色
氣味 (Odor)Practically odorless. Faint, meat-like, mild and sweet taste in aqueous dilutions.
水溶解性Soluble to 10 mM in water and to 100 mM in 1.1eq. NaOH
穩(wěn)定性可在-20°C下的蒸餾水溶液保存長(zhǎng)達(dá)1個(gè)月。
InChIKeyIRJCBFDCFXCWGO-UHFFFAOYSA-N
LogP-1.070 (est)
CAS 數(shù)據(jù)庫(kù)2552-55-8(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301
防范說(shuō)明P264-P270-P301+P310-P405-P501
危險(xiǎn)品標(biāo)志T,Xn
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼23/24/25-25-40
危險(xiǎn)類別碼R23/24/25-R25
安全說(shuō)明45-38-36/37/39-28A-22-36
安全說(shuō)明S45-S38-S36/37/39-S28A-S22
危險(xiǎn)品運(yùn)輸編號(hào)1544
WGK Germany3
RTECS號(hào)NY2100000
危險(xiǎn)等級(jí)6.1(b)
包裝類別III
毒性LD50 in mice, rats (mg/kg): 15, 42 i.v.; 38, 129 orally (Theobald)
常見(jiàn)問(wèn)題列表
生物活性
Ibotenic acid 對(duì) N-甲基-D-天冬氨酸 (NMDA) 和反式-ACPD 或代謝型使君子氨酸 (Qm) 受體位點(diǎn)都具有激動(dòng)劑活性。靶點(diǎn)
NMDA receptor
體外研究
Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC 50 =77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media.