183364-82-1
183364-82-1 結構式
基本信息
中文別名
化合物 T10880 英文別名
CPPGrac-CPPG
(RS)-CPPG
(RS)-α-Cyclopropyl-4-phosphonophenylglycine
(RS)-ALPHA-CYCLOPROPYL-4-PHOSPHONOPHENYLGLYCINE
(+/-)-ALPHA-CYCLOPROPYL-4-PHOSPHONOPHENYLGLYCINE
Benzeneacetic acid, α-amino-α-cyclopropyl-4-phosphono-
常見問題列表
生物活性
CPPG ((RS)-CPPG) 是一種有效的 II/III 型 mGlu 受體拮抗劑。CPPG 對大鼠大腦皮層中的 III 組 (IC50=2.2 nM) 比對 II 組（(IC50=46.2 nM) mGlu 受體有一定的選擇性 (約 20 倍)。CPPG 對 I 組 mGlu 受體的作用較弱。靶點
|
group III mGlu receptors 2.2 nM (IC 50 ) |
group II mGlu receptors 46.2 nM (IC 50 ) |
體外研究
CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC 50 =2.2 nM)- and L-CCG-I (IC 50 =46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells.