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20958-18-3

中文名稱 二氫丹參酮
英文名稱 Dihydrotanshinone
CAS 20958-18-3
分子式 C18H14O3
分子量 278.3
MOL 文件 20958-18-3.mol
更新日期 2024/12/25 14:37:20
20958-18-3 結構式 20958-18-3 結構式

基本信息

中文別名
二氫丹參酮
二氫異丹參酮I
8-二甲基-8
9-二氫菲并[3
2-B]呋喃-7
去氫異丹參酮 I
二氫丹參酮(標準品)
4,8-二甲基-8,9-二氫菲并[3,2-b]呋喃-7,11-二酮
英文別名
DIHYDROTANSHINON
Dihydrotanshinone
Dihydroisotanshinone I
8,9-Dihydro-4,8-dimethylphenanthro[3,2-b]furan-7,11-dione
4,8-Dimethyl-8,9-dihydrophenanthro[3,2-b]furan-7,11-dione
Phenanthro(3,2-B)furan-7,11-dione, 8,9-dihydro-4,8-dimethyl-
4,8-Dimethyl-8,9-Dihydronaphtho[2,1-F][1]BenzofuraN-7,11-Dione
Dihydrotanshinone 4,8-Dimethyl-8,9-dihydrophenanthro[3,2-b]furan-7,11-dione
所屬類別
天然產(chǎn)物:醌類

物理化學性質

沸點470.4±45.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 3.33 mg/mL (11.97 mM; ultrasonic and warming and heat to 40°C)H2O : < 0.1 mg/mL (insoluble)
形態(tài)粉末
顏色紅色

應用領域

用途1
具有抗菌,抗真菌活性,對金黃色葡萄球菌、人型結核桿菌、分支桿菌、真皮菌等都有一定的抑制作用。還有抑制血小板聚集、抗氧化劑、擴張冠狀血管等活性。
二氫丹參酮價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2022/07/01HY-B1919二氫丹參酮
Dihydroisotanshinone I
20958-18-35mg1800元
2022/07/01HY-B1919二氫丹參酮
Dihydroisotanshinone I
20958-18-310mM * 1mLin DMSO2380元
2022/07/01HY-B1919二氫丹參酮
Dihydroisotanshinone I
20958-18-310mg2800元

常見問題列表

生物活性
Dihydroisotanshinone I是一種來自應用廣泛的傳統(tǒng)中藥丹參的活性物質。
靶點

STAT3

體外研究

Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently.

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