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16506-27-7

中文名稱 賓達(dá)氮芥
英文名稱 Bendamustine
CAS 16506-27-7
分子式 C16H21Cl2N3O2
分子量 358.26
MOL 文件 16506-27-7.mol
更新日期 2024/04/02 22:44:43
16506-27-7 結(jié)構(gòu)式 16506-27-7 結(jié)構(gòu)式

基本信息

中文別名
賓達(dá)氮芥
苯達(dá)莫司汀
4-[5-[雙(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸
鹽酸苯達(dá)莫司汀/4-[5-[雙(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸
英文別名
Bendamustine
4-(5-(Bis(2-chloroethyl)
-1-methyl-1H-benzo[d]imidazol-2-yl)
5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid
5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid
4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
1H-BenziMidazole-2-butanoicacid, 5-[bis(2-chloroethyl)aMino]-1-Methyl-
4-(5-(bis(2-chloroethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoic acid

物理化學(xué)性質(zhì)

沸點(diǎn)585.2±50.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C, protect from light
溶解度DMSO : 100 mg/mL (279.13 mM; Need ultrasonic)
酸度系數(shù)(pKa)4.50±0.10(Predicted)
形態(tài)Solid
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H360-H341-H351-H301
毒害物質(zhì)數(shù)據(jù)16506-27-7(Hazardous Substances Data)
賓達(dá)氮芥價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08S5939賓達(dá)氮芥
Bendamustine
16506-27-75mg959.1元
2024/11/08S5939Bendamustine (SDX105)16506-27-710mM (1mL in DMSO)1122.03元
2024/11/08S5939賓達(dá)氮芥
Bendamustine
16506-27-725mg3661.33元

常見問題列表

生物活性
Bendamustine (SDX105)是一種氮芥藥物,用于治療慢性淋巴細(xì)胞白血病、多發(fā)性骨髓瘤和非霍奇金淋巴瘤。
靶點(diǎn)

DNA Alkylator/Crosslinker

體外研究

Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.
Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC 25 s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint.

體內(nèi)研究

Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model.

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