16290-26-9
16290-26-9 結(jié)構(gòu)式
基本信息
3,4-二羥基芐胺氫溴酸鹽
3,4-二羥基芐胺
3,4-二羥基苯甲胺氫溴酸鹽
4-(AMINOMETHYL)CATECHOL HYDROBROMIDE
DHBA
DHBA HYDROBROMIDE
4-(aminomethyl)pyrocatechol hydrobromide
3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE, 9 8%
4-(Aminomethyl)catechol hydrobromide, DHBA hydrobromide
3,4-Dihydroxybenzylamine·hydrogen bromide
4-(Aminomethyl)pyrocatechol·hydrobrominate
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | 22857 | 3,4-二羥基苯甲胺 氫溴酸鹽 3,4-Dihydroxybenzylamine hydrobromide, 98%, Thermo Scientific Chemicals | 16290-26-9 | 250mg | 625元 |
| 2024/11/08 | 22857 | 3,4-二羥基苯甲胺 氫溴酸鹽 3,4-Dihydroxybenzylamine hydrobromide, 98%, Thermo Scientific Chemicals | 16290-26-9 | 1g | 1568元 |
| 2024/11/08 | 22857 | 3,4-二羥基苯甲胺 氫溴酸鹽 3,4-Dihydroxybenzylamine hydrobromide, 98%, Thermo Scientific Chemicals | 16290-26-9 | 5g | 7419元 |
常見問題列表
3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) inhibits the growth of all melanoma cell lines with an IC 50 of 100 μM, while the SK-MELB cell line exhibits an IC 50 of 122 μM. The IC 50 values are 30, 84,90, and 68 μM for Human SK-MEL-30, SK-MEL-2, SK-MEL-3,RPMI-7951 cells, respectively. It exhibits IC 50 values of 10, 25, 67, and 184 μM for S91A,S91B, L1210, and SCC-25 cells, respectively.3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) cytotoxicity in SK-MEL-2 and SK-MEL-28 cell lines can be enhanced by application of buthionine sulfoximine (BSO). BSO treatment sensitizes marginally pigmented cells to the effects of 3,4-DHBA, and the presence of decreses IC 50 values of 3,4-DHBA by 127% in the SK-MEL-28 cell line and by 148% in the SK-MEL-2 cell line.
Cell Viability Assay
| Cell Line: | Human and Murine Melanoma Cell Lines; Non-Melanoma Cell Lines |
| Concentration: | 1 μM-10 mM |
| Incubation Time: | 48 hours |
| Result: | Inhibited melanoma cell Lines growth. |
3,4-Dihydroxybenzylamine hydrobromide (intraperitoneal injection; 1000 mg/kg; 7 days) has the least toxic effect in non-tumor-bearing B6D2F1 mice,and mice is tolerated at this dose. 3,4-Dihydroxybenzylamine hydrobromide (intraperitoneal injection; 200-800 mg/kg; 21 days) has different effects at different doses, the median life-span are 17, 24.5, 26, 29 and 25 days for 0 mg/kg, 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg, respectively.
| Animal Model: | C57BL/6 mice with B6D2F1 cells |
| Dosage: | 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Exhibited increased life-span of 44%,46%, 70% and 50% for 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg, respectively. |