147419-93-0
147419-93-0 結(jié)構(gòu)式
基本信息
人參皂甙 RB6
人參皂苷, 來源于人參
人參皂苷RG6對照品,
Ginsenoside Rg6 USP/EP/BP
Ginsenoside Rg6, 98%, from Panax ginseng C. A. Mey.
daMMar-20(21),24-diene-3β,6α,12β-trihydroxy-6-O-α-L-rhaMnopyranosyl(-1→2)-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,6α,12β)-3,12-dihydroxydammara-20,24-dien-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-
b-D-Glucopyranoside, (3b,6a,12b)-3,12-dihydroxydammara-20,24-dien-6-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-
(3beta,6alpha,12beta)-3,12-Dihydroxydammara-20,24-dien-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
物理化學(xué)性質(zhì)
常見問題列表
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NF-κB 25.12 μM (IC 50 , in SK-Hep1 cell) |
NF-κB 29.34 μM (IC 50 , in HepG2 cell) |
Apoptosis
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Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC 50 of 25.12±1.04 μM in SK-Hep1 cells, consistent with the data from HepG2 cells. Ginsenoside Rg6 exhibits obvious anti-proliferative and apoptosis-inducing effects when it is applied to JK cells in vitro. Ginsenoside Rg6 blocks S arrest in the cell cycle. CCK-8 method shows that after Ginsenoside Rg6 is used, several groups with different concentrations obviously inhibits JK cell proliferation in human lymphocytoma, with evident dose dependency. Based on IC 50 , the median inhibitory concentration of Ginsenoside Rg6 is 83.08 μM.